High purity 99.5% ...

High purity 99.5% in bulk supply Linagliptin 668270-12-0 in stock
High purity 99.5% in bulk supply Linagliptin 668270-12-0 in stock
High purity 99.5% in bulk supply Linagliptin 668270-12-0 in stock
High purity 99.5% in bulk supply Linagliptin 668270-12-0 in stock

High purity 99.5% in bulk supply Linagliptin 668270-12-0 in stock

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Linagliptin 668270-12-0 in stock High purity 99.5% Linagliptin Linagliptin 668270-12-0 in bulk supply

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  • Appearance:As per Certificate of analysis
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High purity 99.5%  in bulk supply Linagliptin 668270-12-0 in stock

Product Name: Linagliptin
Synonyms: Tradjenta;Linagliptin-D4;Linagliptin (BI-1356);Linaglitine;(R)-8-(3-aMinopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-1H-purine-2,6(3H,7H)-dione;Linagliptin API;Lillidine;1H-Purine-2,6-dione,8-[(3R)-3-aMino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-Methyl-1-[(4-Methyl-2-quinazolinyl)Methyl]-
CAS: 668270-12-0
MF: C25H28N8O2
MW: 472.54
EINECS: 1308068-626-2
Product Categories: Pharmaceutical raw material;Inhibitor;Linagliptin;TRADJENTA;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API
Mol File: 668270-12-0.mol
Linagliptin Structure
Linagliptin Usage And Synthesis
Uses
Linagliptin (TrajentaR, TradjentaTM, TrazentaTM, TrayentaTM) is an oral, highly selective inhibitor of dipeptidyl peptidase-4 and is the first agent of its class to be eliminated predominantly via a nonrenal route. Linagliptin is indicated for once daily use for the treatment of adults with type 2 diabetes mellitus.
 
Treatment of Type 2 diabetes
Linagliptin acts to lower blood glucose levels by inhibiting the enzyme DPP-4, thereby preventing the degradation of the incretin hormones (glucagon-like peptide-1 [GLP-1] and glucose-dependent insulinotropic peptide) and attenuating postprandial glucose excursions. By selectively targeting DPP-4, linagliptin potentially causes a more physiologically based control of glucose-dependent postprandial glucose excursions and of fasting blood glucose, both of which are mediated by effects of glucose on insulin and glucagon secretion. An advantage of linagliptin is that since incretin-stimulated release of insulin is glucose dependent, linagliptin is associated with a low incidence of hypoglycaemia. Moreover, DPP-4 inhibitors have a low potential for drug-drug interactions (with the exception of saxagliptin, which is metabolized by cytochrome P450 [CYP] 3A4/5), are generally well tolerated and have minimal or neutral effects on bodyweight. 
 
Pharmacokinetics
Linagliptin shows modest oral bioavailability, and it is rapidly absorbed. The maximum plasma concentration at steady state is reached on average 1.5 hours after administration of linagliptin 5 mg, once daily . Linagliptin half-life is 131 hours. No relevant food effects were observed on the absorption profile of linagliptin. Unlike other DPP-4 inhibitors, linagliptin excretion is not performed by the kidneys, but rather through the enterohepatic system.

Details:

Product Name: Linagliptin

Synonyms: 8-[(3R)-3-Amino-1-piperidinyl]-7-(2-butynyl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione

CAS NO.: 668270-12-0

Molecular Formula: C25H28N8O2

Molecular Weight: 472.54


Molecular Structure: 
 
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