1204144-28-4 Good Supplier In China 1204144-28-4 on hot selling Pharmaceutical grade AZD-1208

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1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 98%
Payment Terms : T/T,Other

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1204144-28-4 Good Supplier In China 1204144-28-4 on hot selling Pharmaceutical grade AZD-1208

Quick Details

Appearance:Powder
Application:Scientific research
PackAge:As required
ProductionCapacity:1000|Gram|Week
Storage:keep sealed and keep from direct light
Transportation:By Sea/Air/FedEx

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1204144-28-4 Good Supplier In China 1204144-28-4 on hot selling Pharmaceutical grade AZD-1208

AZD 1208 is a potent pan Pim kinase inhibitor (IC₅₀ values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. Chemosensitizer.

AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC₅₀s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively). It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16 xenograft tumors in mice. It has efficacy against acute myeloid leukemia and glioblastoma cells when combined with mTOR and p110α inhibitors, respectively.

Details:

Alternate Name	5-[[2-[(3R)-3-Aminopiperidin-1-yl]biphenyl-3-yl]methylidene]-1,3-thiazolidine-2,4-dione
Appearance	Pale yellow solid
CAS #	1204144-28-4
Molecular Formula	C??H??N?O?S
Molecular Weight	379.48
Purity	≥98% by HPLC
Solubility	DMSO
SMILES	C1CC(CN(C1)C2=C(C=CC=C2C=C3C(=O)NC(=O)S3)C4=CC=CC=C4)N
InChi	InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1
InChi Key	MCUJKPPARUPFJM-UWCCDQBKSA-N
PubChem CID	58423153
Handling	Protect from air and light
Storage Conditions	-20°C
Shipping Conditions	Gel Pack

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