Perampanel intermediates Phenylboronic acid

Perampanel intermediates Phenylboronic acid

Min.Order / FOB Price:Get Latest Price

1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: HPLC>99.0%
Payment Terms : L/C,D/A,D/P,T/T

Keywords

Perampanel intermediates 99.0% min Phenylboronic acid Flurbiprofen intermediates

Quick Details

Appearance:white powder
Application:OLED materia, Perampanel intermediates, flurbiprofen
PackAge:Net 20kg/drum
ProductionCapacity:10|Metric Ton|Month
Storage:room temperature, keep dry
Transportation:on request

Superiority:

Hebei Maison Chemical Co.,Ltd ,established in Year 2006, with total 140 members, our factory has more than 120 set of large-scale reactors which can be used to conduct high temperature, high pressure and ultra low temperature reactions. Our facility has rectification, molecular Short-path distillation and other refining workshop together with a testing room equipped with GC, HPLC and other detecting instruments. We have passed ISO9001 certification in 2008, as well as established a complete quality control system to ensure production is efficient, steady and controllable.

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Details:

Phenylboronic acid is used in numerous cross coupling reactions. In 1979, Miyarura and Suzuki found a carbon-carbon bond forming reaction (now called a Suzuki reaction) using alkenyl boranes, aryl halides, catalytic Pd(0), and base to produce arylated alkene products. This method was generalized to a route producing biaryls by coupling phenylboronic acid with aryl halides.

More C-C bond forming processes commonly use phenylboronic acid as a reagent. Alpha-amino acids can be generated using the uncatalyzed reaction between alpha-ketoacids, amines, and phenylboronic acid. Heck-type cross coupling of phenylboronic acid to alkenes and alkynes. This unique C-C bond forming reaction has the ability to couple a terminal olefin with boronic acid using a transition metal catalyst. Aryl azides and nitroaromatics can also be generated using phenylboronic acid.PhB(OH)₂ can be used as a protecting group for diols and diamines. Phenylboronic acid can also be regioselectively halodeboronated using aqueous bromine, chlorine, or iodine.

PhB(OH)₂ + Br₂+ H₂O → PhBr + B(OH)₃ + HBr
Phenylboronic acid is used in biology schemes as receptors and sensors for carbohydrates, antimicrobial agents and enzyme inhibitors, neutron capture therapy for cancer, transmembrane transport, and bioconjugation and labeling of proteins and cell surface.

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