AZD9291 Osimertinib Mesylate CAS 1421373-65-0
Product name: Osimertinib Mesylate/AZD9291
CAS NO: 1421373-65-0
Name:AZD-9291,AZD9291
Synonyms:N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
Molecular formula : C28H33N7O2.CH4O3S
Molecular weight:595.71
Product name:
Osimertinib (previously known as mereletinib or AZD9291) is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor drug.
AZD9291 is a Kinase Inhibitor. The mechanism of action of osimertinib is as a Kinase Inhibitor, and Cytochrome P450 3A Inhibitor, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 1A2 Inducer, and Breast Cancer Resistance Protein Inhibitor.
As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors which also inhibit wild-type EGFR.
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