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1 Gram |
Negotiable |
Cabozantinib XL184 XL-184
Name | Cabozantinib |
Purity | 99.0% min. |
Appearance | White to off-white solid |
Synonym | N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
CAS No. | Cabozantinib has the CAS number being 849217-68-1 |
Molecular Formula | Cabozantinib has the molecular formula being C28H24FN3O5 |
Molecular Weight | Cabozantinib has the molecular weight being 501.51 |
Cabozantinib is a small molecule inhibitor that effectively inhibits receptor targets including MET, AXL, and VEGFR-1, VEGFR-2, and VEGFR-3. These receptors are involved in a series of disease-related processes such as tumor angiogenesis, invasion, metastasis and drug resistance. CABOMETYX tablets are approved for the treatment of patients with advanced renal cell carcinoma (RCC) in the United States. CABOMETYX tablets have also been approved by the European Union, Norway, Iceland and Switzerland for advanced RCC adult patients who have received prior vascular endothelial growth factor (VEGF) targeted therapies.
Function:
Cabozantinib is indicated for the treatment of advanced, metastatic medullary thyroid carcinoma (MTC) patients; patients with advanced non-small cell lung cancer (NSCLC) with C-met expansion. It is suitable for advanced renal cell carcinoma that has undergone anti-angiogenic therapy; it is suitable for medullary thyroid cancer that cannot be surgically removed; it is suitable for patients with liver cancer who have been treated with NEXAVAR; it is suitable for patients with advanced prostate cancer who have bone metastases.
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