Larotrectinib LOXO-101 LOXO101
LOXO-101 is a potent, ATP-competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100-fold selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
Product Name: LOXO-101
Alternate Name 3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide; ARRY 470; Larotrectinib
Appearance: Crystalline solid
CAS No.: 1223403-58-4
Molecular Formula: C21H22F2N6O2
Molecular Weight: 428.44
Purity: ≥99%
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