Tributyrin / premium alternative to antibiotic

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Mechanism of Tributyrin

The intestinal mucosa has the physiological function of absorbing nutrients and immune barrier function. Modern nutritional physiology studies have shown that the mucosal barrier plays a key role in the absorption of nutrients and disease prevention and control. The shape, structure and function of animal intestinal mucosa are affected by many factors, such as animal age, nutrition, pathogenic microorganisms and environment. In the juvenile period of animals, the structure and function of the intestinal mucosa are not fully developed. Some stress factors (such as weaning) also significantly affect the structure and function of the intestinal mucosa, leading to the destruction of the barrier function of the intestinal mucosa, and ultimately affecting the health and Grow.

Intestinal mucosa is the fastest growing tissue in the early stage of animal growth, and one of the fastest renewal tissues in the animal body. Rapid growth and continuous renewal require effective energy and various nutrients. Therefore, the intestinal mucosa is the most nutrient sensitive tissue in the animal body. The repair of intestinal mucosal damage caused by some stress factors (such as weaning) requires more energy and nutrients. The intestinal tract accounts for about 24% of the energy needed by pigs for maintenance. Intestinal epithelial renewal involves the migration of mucosal cells, that is, the migration of cells from crypts to villi, which is an energy-consuming process. Reducing the renewal of intestinal epithelial cells will save energy for growth. Effective energy is the guarantee for the normal renewal of intestinal epithelium.

The functional unit of the small intestine is villi. The functional cells of villi. Intestinal epithelial cells originate from different crypt cells. In the crypts, intestinal epithelial cells are secretory. When it migrates to the side of the villi, it matures into absorbed villi cells. , The microvilli become longer and the number of cells increases. If the apex of the villi is damaged, the mature absorption cells are lost, and the immature crypt cells produce net secretion consequences, resulting in serious villi cell renewal digestion and absorption disorders. Histologically, the shortening and fusion of the villi is the so-called "villus atrophy", which leads to a decrease in the functional surface area of the mucosa, a decrease in absorption capacity, and diarrhea in piglets.

The root cause of the changes in the structure of the small intestine villi is the insufficient supply of effective energy to the mucosal cells, which will inevitably lead to the endogenous "starvation" of the intestinal cells, which cannot maintain normal renewal and repair tissue damage.

Due to a series of stress factors including physiological, psychological, environmental and nutritional factors (such as feed antigens), resulting in intestinal structure and function damage, such as intestinal villi atrophy and crypt hyperplasia; digestive tract enzyme activity decreased, Reduced immune function; reduced digestion and absorption capacity of the small intestine, etc. Production is manifested by decreased feed intake, growth retardation and diarrhea. To solve these problems, a good diet must be provided. A good diet composition can reduce the energy required for intestinal mucosal cell migration, provide effective energy nutrition, and repair the intestinal structure and function damage caused by weaning stress.

Tributyrin will not be decomposed in gastric juice, so it can all pass the stomach ,and then in the intestinal tract, it will be slowly released into butyric acid and glycerol under the action of intestinal lipase. Butyric acid is a short-chain fatty acid and the main energy source of intestinal epithelial cells. It can significantly stimulate the proliferation of intestinal epithelial cells and increase the height of small intestinal villi, thereby promoting nutrient absorption, enhancing immunity, and improving animal health, thereby overcoming piglet weaning stress Syndrome, improve production performance and reduce mortality.