Oleoyl ethanolamide

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Product introduction

 OEA is derived from the omega-9 monounsaturated fatty acid oleic acid. It is considered an endocannabinoid-like lipid, a receptor activated by peroxisome proliferator alpha (PPAR-alpha) that interacts with and mediates anti-inflammatory processes. The bioactive lipid amide OEA is synthesized in the gastrointestinal tract and is associated with multiple unique homeostatic properties, including anti-inflammatory activity, immune response, stimulation of lipolysis, and fatty acid oxidation. Furthermore, the fatty acid ethanolamide is a lipid mediator that regulates a large number of physiological functions. As a biologically active lipid mediator, oleoylethanolamide (OEA) is a potent agonist of peroxisome proliferator-activated receptor-α (PPAR-α) and can regulate the increased expression of fatty acid transferase CD36 , thereby regulating eating behavior. In addition, OEA is an endogenous fatty acid ethanolamine produced in the intestinal mucosa.  OEA anorexigenic signaling may be an essential element of the physiological and metabolic systems that regulate dietary fat intake and obesity. Ingestion of oleic acid, and the resulting OEA that confers anorexic characteristics, depends on CD36, PPAR-α, intestinal fat sensory receptors, histamine, oxytocin, and dopamine; leading to increased fat oxidation and energy expenditure, thereby producing a feeling of satiety and increases feeding latency; any disruption in these systems halts or inhibits fat-induced satiety.