CAS 73-31-4 Melatonin supplier Melatonin low price Melatonin Kosher

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CAS 73-31-4 Melatonin supplier Melatonin low price Melatonin Kosher

Medical uses

In the European Union it is indicated for the treatment of insomnia in children and adolescents aged 2–18 with autism spectrum disorder (ASD) and / or Smith–Magenis syndrome, where sleep hygiene measures have been insufficient[12] and for monotherapy for the short-term treatment of primary insomnia characterized by poor quality of sleep in people who are aged 55 or over.

Sleep disorders

Positions on the benefits of melatonin for insomnia are mixed. A review by the Agency for Healthcare Research and Quality (AHRQ) from 2015 stated that evidence of benefit in the general population was unclear.A review from 2017, found a modest effect on time until onset of sleep.Another review from 2017 put this decrease at six minutes to sleep onset but found no difference in total sleep time. Melatonin may also be useful in delayed sleep phase syndrome.Melatonin appears to work as well as ramelteon but costs less.

Melatonin is a safer alternative than clonazepam in the treatment of REM sleep behavior disorder – a condition associated with the synucleinopathies like Parkinson's disease and dementia with Lewy bodies.In Europe it is used for short-term treatment of insomnia in people who are 55 years old or older. It is deemed to be a first line agent in this group.

Melatonin reduces the time until onset of sleep and increases sleep duration in children with neurodevelopmental disorders.

Dementia

A 2020 Cochrane review found no evidence that melatonin helped sleep problems in people with moderate to severe dementia due to Alzheimer's disease.A 2019 review found that while melatonin may improve sleep in minimal cognitive impairment, after the onset of Alzheimer's it has little to no effect.Melatonin may, however, help with sundowning.

Jet lag and shift work

Melatonin is known to reduce jet lag, especially in eastward travel. If the time it is taken is not correct, however, it can instead delay adaptation.

Melatonin appears to have limited use against the sleep problems of people who work shift work.Tentative evidence suggests that it increases the length of time people are able to sleep.a