Piceatannol Kosher 10083-24-6 Piceatannol HALAL Fast Delivery C14H12O4

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0 Metric Ton	Negotiable

0 Metric Ton

Negotiable

Min.Order :0 Metric Ton
Purity: 98%min

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Piceatannol Kosher Piceatannol HALAL Fast Delivery manufacturer 10083-24-6 Piceatannol

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Appearance:white powder
Application:Mainly used in the pharmaceutical industry, chemical industry and so on
PackAge:according to the clients requirement
ProductionCapacity:500|Metric Ton|Day
Storage:Store at a cool, dry place
Transportation:as your need

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Piceatannol Kosher 10083-24-6 Piceatannol HALAL Fast Delivery C14H12O4

Piceatannol, alias 3' -hydroxyresveratrol, CAS number 10083-24-6, is an anti-inflammatory, immunomodulatory, and anti-proliferative agent. It inhibited p56LCK and SYK protein tyrosine kinases, and inhibited NF-κB activation and gene expression of TNF-κB. It is synthesized by converting the cytochrome P4501B1 into resveratrol. So what is its biological activity? How do you do the experiment?

First, we introduce the biological activity of pyruvic alcohol:

1) In vitro activity

In mast cells, peregritol is a potent histamine release inhibitor. It inhibited the proliferation of CAP cells in androgen-dependent or non-dependent manner, and significantly reduced the expression of mTOR and its key effectors, Akt and eIF4EBP-1.

It also effectively inhibited CDPK, MLCK, PKC and PKA (IC50 was 19μM, 12μM, 8μM, 3μM, respectively). Pyracitol selectively inhibited the phosphorylation of STAT3/5 tyrosine induced by IFNα, but did not affect STAT1/2, and selectively inhibited the dephosphorylation of JAK1 and IFNAR1 tyrosine, but did not affect TYK2 and IFNAR2. The apoptosis of Bjabburkitt-like lymphoma cells was effectively induced by pyelitol through activation of caspase-3 and changes in mitochondrial permeability, with ED50 of 25 μm, independent of the CD95/Fas signaling pathway.

Picranitol selectively inhibits SYK in mast cells and thus blocks receptor-mediated downstream cellular responses, including inhibition of 1,4,5-IP3 secretion, synthesis, membrane margin fluctuations, and transport. The inhibitory effect of pyelitol on SYK was about 10 times higher than that of Lyn. The phosphorylation of antigen-stimulated SYK and most other cellular proteins in RBL-2H3 cells was strongly inhibited by leucocitol treatment, but the inhibition was dose-dependent on the phosphorylation of receptor γ or β subtypes.

Picarboxyl inhibited the activation of NF-κB induced by TNF,H2O2,PMA, lipopolysaccharide, Okadasic acid, and ceramide. Picranitol inhibited TNF-induced expression of NF-κB-dependent reporter genes (matrix metalloproteinase-9, cyclinase-2, and cyclinD1) by blocking TNF-induced IκBαof, p65 phosphorylation, p65 nuclear translocation, and IκBα kinase activation, independent of tyrosine kinase. Pyrutaxitol inhibits the activity of the enzyme by directly binding to intracellular phosphatidylinositol kinase in a competitive way through adenosine triphosphate, and its anti-hardening effect is better than resveratrol's anti-atherosclerosis effect.

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2) In vivo activity

In the treatment of mice with BALB/c colitis induced by sodium dextran sulfate, oral administration of leucitol significantly improved the destruction of colon structure, significantly reduced the production of inflammatory mediators (such as nitric oxide, prostagland E2, and proinflammatory cytokines), and significantly reduced the activity of MPO in the colonic medullary. In DB/DB mouse models of type 2 diabetes, percedranol inhibits early elevation of blood glucose levels and improves impaired glucose tolerance symptoms in later stages.

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