Bendopa Dopaston Prodopa
1. Introduction of Levodopa
Levodopa, with the IUPAC Name of (2S)-2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid, is one kind of colorless crystalline powder. This product belongs to the Product Category which include Pharmaceutical; Amino Acids; Biochemistry; Biological-modified Amino Acids; Nutritional Supplements; Natural Plant Extract. Besides, Levodopa could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
2. Properties of Levodopa
Levodopa has the following datas: (1)Index of Refraction: 1.654; (2)Molar Refractivity: 49.25 cm3; (3)Molar Volume: 134.2 cm3 ; (4)Surface Tension: 80.2 dyne/cm; (5)Density: 1.468 g/cm3; (6)Flash Point: 225 °C; (7)Enthalpy of Vaporization: 74.5 kJ/mol; (8)Boiling Point: 448.4 °C at 760 mmHg; (9)Vapour Pressure: 7.97E-09 mmHg at 25 °C; (10) Melting point: 276-278 °C(lit.); (11)Storage tempreture: 2-8 °C.
Index Name |
Index |
Test results |
Appearance |
White to off- white powder |
Conform |
Identification |
The retention time of the major peak of the sample solution to that the standard solution, as obtained in assay |
Conform |
Optical rotation |
-160°~ -167° |
-163.4° |
Organic impurities |
Levodopa related compound A≤0.1% |
ND |
|
L-Tyrosine ≤% |
ND |
|
Levodopa related compound B≤0.5% |
ND |
|
Individual unkown impurity ≤ 0.1% |
ND |
|
Total impurities ≤1.0% |
ND |
Loss on drying % |
≤ 0.5 |
0.24 |
Residue on ignition % |
≤0.1 |
0.09 |
Heavy metal(pb) |
≤20ppm |
≤20ppm |
Assay ( HPLC)% |
98.0-102.0 |
99.8 |
Conclusion |
Qualified with USP standard |
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