Preparation of tris hydroxymethyl aminomethane

Details:

Title：Tris  CAS77-86-1

【Name】Trometamol

【Abbreviation】Tris

【CAS#】77-86-1

【Molecular weight】121.135

【Molecular formula】C4H11NO3

【Storage Conditions】Room temperature, light-proof and moisture-proof

【Appearance】White crystal powder

【Molecular structure】

The synthesis process of trimethylol aminomethane is as follows

1. Preparation method of trihydroxymethyl aminomethane: adding trihydroxymethyl methane into methanol water solution, heating to 50-70 ℃, stirring and dissolving, wherein the mass volume ratio of trihydroxymethyl methane and methanol water solution is 8:3-7 according to g / ml, and the methanol water solution is prepared by mixing pure water and methanol according to the volume ratio of 2:3; Adding charcoal activated carbon to the solution, wherein the weight ratio of charcoal activated carbon to trimethylolmethane is 0.5-2:100, holding at 45-55 ℃ for 20-40 minutes, filtering while hot, and collecting the filtrate; The filtrate is concentrated under reduced pressure at 70-80 ℃ until crystallization occurs, and then put in a cool place; After the crystallization is separated by suction filtration, it is washed with absolute ethanol and dried at 40-60 ℃ for 3-5 hours.

2. The synthesis method of trimethylol aminomethane: it uses nitromethane and excessive paraformaldehyde as the main raw materials, and condenses to trimethylol nitromethane at a certain temperature; Then, under a certain temperature, pressure, solvent and catalyst, trihydroxymethyl aminomethane was prepared by hydroreduction reaction, crystallization and recrystallization.

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