77-52-1 ursolic acid factory in China

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price: USD 1.0000

1 Kilogram

FOB Price: USD 1.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : T/T

Keywords

77-52-1 ursolic acid factory ursolic acid 77-52-1 in China ursolic acid 77-52-1

Quick Details

Appearance:White powder
Application:Cosmetic medicine
PackAge:25KGS CARDBOARD DRUMS
ProductionCapacity:25|Kilogram|Day
Storage:Cool and normal temperature warehouse
Transportation:by air by sea

Superiority:

Ursolic acid (77-52-1) inhibits endothelial cell proliferation and migration (IC₅₀=5 µM) and angiogenesis. Promotes skeletal muscle rejuvenation via enhanced SIRT1 expression. Induces apoptosis in malignant mesothelioma cells

Ursolic acid is a pentacyclic triterpenoid that has been isolated from M. pumila and has diverse biological activities, including anticancer, hepatoprotective, anti-inflammatory, antioxidant, antimicrobial, and cardioprotective properties. It inhibits the proliferation of HepG2 liver, MCF-7 breast, and Caco-2 colon cancer cells (EC₅₀s = 87.4, 14.4, and 34.4 μM, respectively). Ursolic acid reverses increases in hepatic steatosis, levels of hepatic triglycerides and free fatty acids, and hepatic TNF-α, IL-1β, IL-6, and IL-8 mRNA expression in a dose-dependent manner in a high-fat diet-induced rat model of non-alcoholic fatty liver disease (NAFLD). Ursolic acid also scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC₅₀ = 59.7 μg/ml) and inhibits the growth of several strains of Gram-positive and Gram-negative bacteria in vitro including S. aureus, E. coli, P. aeruginosa, K. pneumoniae, and S. flexneri (MICs = 32-512 μg/ml)

Details:

Ursolic acid (UA) (3β-hydroxy-urs-12-en-28-oic-acid) (Fig. 1) is a pentacyclic triterpenoid carboxylic compound (C30H48O3) which may occur in the free acid form or as aglycones for triterpenoid saponins. Its isomer, oleanolic acid (OA) (3β-hydroxy-olea-12-en-28-oic-acid), presents different substitution of the methyl group, but they have similar molecular structures and pharmacological activity. Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet, once they are found in fruits and medicinal herbs.

Product name

Ursolic acid, Pentacyclic triterpenoid
Description

Pentacyclic triterpenoid; antitumourigenic.
Biological description

Pentacyclic triterpenoid. Suppresses NF-κB activation in vitro. Antitumourigenic, antiangiogenic, anti-inflammatory and proapoptotic effects.
Purity

> 99%
CAS Number

77-52-1
Chemical structure

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