The role of sodium citrate in blood collection

Details:

Trisodium citrate, also known as sodium citrate, is an organic compound with white to colorless crystal appearance. Odorless, cool, salty and spicy. It is stable in normal temperature and air, slightly soluble in wet air, and weathered in hot air. When heated to 150 ℃, crystal water will be lost. It is easy to dissolve in water, glycerin, alcohols and other organic solvents. It decomposes at high temperature, deliquescence in humid environment and weathering in hot air. The pH value of the solution is about 8.

Trisodium citrate has very good solubility, and the solubility increases with the increase of water temperature. Trisodium citrate is a kind of weak acid and strong base salt, which can form a strong pH buffer with citric acid. In medicine, trisodium citrate can be used as anticoagulant and blood transfusion, prolong the shelf life of blood products, adjust the acidity of urine, multivalent complexing agent and multivalent chelating agent to remove trace metals.

In addition, trisodium citrate is widely used in food, industry, medicine and other fields. And the main component of trisodium citrate is citric acid, and citric acid is a natural ingredient, which will not cause harm to the body.

So how to prepare trisodium citrate

The synthetic method of trisodium citrate is that citric acid is oxidized by hydrogen or neutralized by sodium bicarbonate. Dissolve sodium bicarbonate in water under stirring and heating, add citric acid, continue to raise the temperature to 85 ~ 90 ℃, adjust the pH to 6.8, add activated carbon to decolorize, and filter while it is hot. The filtrate was concentrated under reduced pressure, cooled, crystallized, filtered, washed and dried to obtain trisodium citrate.

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