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102-32-9 manufacturer 102-32-9 in stock Supply 3,4-dihydroxyphenylacetic acid(DOPAC)
3,4-Dihydroxyphenylacetic acid is an important metabolite when studying the behavior of the dopaminergic system. 3,4-Dihydroxyphenylacetic acid is a phenol isolated from Arbutus unedo. It has antioxidant activity and exhibits both superoxide dismutase-like and DPPH radical scavenging activities.
(3,4-dihydroxyphenyl)acetic acid is a dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine. It has a role as a human metabolite. It is a dihydroxyphenylacetic acid and a member of catechols. It derives from a phenylacetic acid. It is a conjugate acid of a (3,4-dihydroxyphenyl)acetate.
3,4-Dihydroxyphenylacetic acid is intended for Pharmaceuticals applications. All information about 3,4-Dihydroxyphenylacetic acid is provided in the MSDS. We deliver compounds with high purity levels and a comprehensive Certificate of Analysis. Connect to your member account to consult the documents.
3,4-dihydroxyphenylacetic acid (DOPAC) is a metabolite of dopamine formed through deamination by monoamine oxidase (MAO). DOPAC is further metabolized by catechol-O-methyltransferase (COMT) to form homovanillic acid, and DOPAC levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens, striatum, and prefrontal cortex of COMT knockout mice. DOPAC oxidation is catalyzed by α-synuclein and oxidized DOPAC binds to monomeric α-synuclein preventing fibrillation. In vivo, foot shock stress increases DOPAC levels relative to control by approximately 45% in the prefrontal cortex and by 15% in the olfactory tubercles and ventral tegmental area (VTA) in rats.
Catalogue Number | D454250 |
Chemical Name | 3,4-Dihydroxyphenylacetic Acid |
Synonyms | 3,4-Dihydroxybenzeneacetic Acid; (3,4-Dihydroxyphenyl)acetic Acid; Ba 2773; DOPAC; Dihydroxyphenylacetic Acid; Dopacetic Acid; Homoprotocatechuic Acid; |
CAS Number | 102-32-9 |
Molecular Formula | C8H8O4 |
Appearance | Pale Brown to Dark Brown Solid |
Melting Point | 130-133°C |
Molecular Weight | 168.15 |
Storage | Refrigerator |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Category | Standards; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | 3,4-Dihydroxyphenylacetic Acid is a metabolite of Dopamine (D533782). |
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