Anticoagulant effect and application of heparin

Details:

Heparin is called heparin because it exists in all mammals. It is extracted from the liver tissue of mammals at first. It is synthesized in mast cells and basophils and stored in the secretory granules of these cells. Because mast cells exist in many tissues, heparin on the market is generally extracted from the large intestinal mucosa of pigs.

Heparin lithium powder

Heparin prevents blood clotting because it contains a unique pentasaccharide sequence that binds closely to antithrombin III. Antithrombin III is a plasma protein that inhibits coagulation by binding to a variety of activated coagulation factors, including factors Xia, Xa, IXA and IIA (thrombin). Like other coagulation cascade inhibitors, the physiological function of antithrombin III is to prevent blood coagulation in vivo, so as to maintain the blood flow in intact vessels. The effect of heparin binding is to increase antithrombin III activity by more than 1000 times.

Because heparin has little interference on blood components, it has no effect on the size of red blood cells and will not cause hemolysis. It also has the advantages of high separation speed, wide operating temperature range and good compatibility with serum indexes. Heparin is often used as an additive in blood collection vessel. Heparin lithium or heparin sodium is sprayed in blood collection vessel and used as anticoagulant tube. It is mainly used in clinical plasma, emergency biochemistry, hemorheology and other detection items. Because heparin lithium has no effect on sodium ion, it can also be used for trace element detection and more detection experiments.

Desheng company specializes in the production of vascular additive series products. It has been more than ten years since the establishment of the company. Its main products include heparin sodium, heparin lithium, serum gel, EDTA dipotassium / Tripotassium, coagulant, coagulant powder and other products. It has a professional team to manage R & D and production. If you are interested in Desheng's products, you can go to its official website to contact customer service for details.