1876467-74-1 BAY-18...

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1876467-74-1 BAY-1895344 HCl best quality 1876467-74-1 Wholesaler 1876467-74-1

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1876467-74-1 BAY-1895344 HCl best quality 1876467-74-1 Wholesaler 1876467-74-1

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1876467-74-1 BAY-1895344 HCl best quality 1876467-74-1 Wholesaler 

Elimusertib, also known as BAY-1895344, is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.

BAY-1895344 is an inhibitor of ataxia-telangiectasia and Rad3-related protein/kinase (ATR; IC50 = 0.007 µM). It is selective for ATR over DNA protein kinase (DNA-PK), ataxia-telangiectasia mutated kinase (ATM), and PI3Kβ (IC50s = 0.332, 1.42, and 3.27 µM, respectively). BAY-1895344 inhibits proliferation of HT-29 and LoVo colorectal cancer cells and SU-DHL-8 B lymphoma cells with IC50 values of 0.16, 0.071, and 0.009 µM, respectively. It reduces tumor growth in a mutant ATMK1964E-containing SU-DHL-8 mouse xenograft model when administered at a dose of 50 mg/kg. BAY-1895344 is synergistic with carboplatin, olaparib, or radiation in various mouse xenograft models.

Details:

Catalogue Number B118925
Chemical Name BAY-1895344
Synonyms (R)-3-Methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine; 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine
CAS Number 1876467-74-1
Molecular Formula C??H??N?O
Appearance Orange Solid
Melting Point >200°C (dec.)
Molecular Weight 375.43
Storage Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
Category Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor used in the treatment of advanced hyperproliferative disease, prophylaxis, solid tumors and lymphomas.

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