1361951-15-6 good s...

1361951-15-6 good supplier fast delivery 1361951-15-6 TP-3654 Hot sale 1361951-15-6
1361951-15-6 good supplier fast delivery 1361951-15-6 TP-3654 Hot sale 1361951-15-6

1361951-15-6 good supplier fast delivery 1361951-15-6 TP-3654 Hot sale 1361951-15-6

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1 Gram

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  • Min.Order :1 Gram
  • Purity: 98%
  • Payment Terms : T/T,Other

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TP-3654 TP-3654; TP3654; TP 3654 1361951-15-6

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  • Appearance:Powder
  • Application:Scientific research
  • PackAge:As required
  • ProductionCapacity:1000|Gram|Week
  • Storage:keep sealed and keep from direct light
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1361951-15-6 good supplier fast delivery 1361951-15-6 TP-3654 Hot sale

TP-3654 is an inhibitor of Pim kinases (Kis = 5, 239, and 42 nM for Pim-1, Pim-2, and Pim-3, respectively). It inhibits 19 additional kinases, including PI3Kα, PI3Kγ, and PI3Kδ, with IC50 values of less than 300 nM. TP-3654 inhibits phosphorylation of Bad in HEK293 cells overexpressing Bad and Pim-1 (EC50 = 67 nM), as well as in UM-UC-3 cells. It reduces tumor growth in UM-UC-3 bladder carcinoma and PC3 prostate adenocarcinoma mouse xenograft models when administered at a dose of 200 mg/kg.

Alternate Name2-((1R,4R)-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-olAppearanceWhite to off-white solidCAS #1361951-15-6Molecular FormulaC??H2??F?N?OMolecular Weight418.46Purity≥98% by HPLCSolubilityDMSOSMILESCC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)OInChiInChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)InChi KeyXRNVABDYQLHODA-UHFFFAOYSA-NPubChem CID66598080HandlingProtect from air and lightStorage Conditions-20°CShipping ConditionsGel PackUSAGEFor Research Use Only! Not For Use in Humans.

Details:

Alternate Name 2-((1R,4R)-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
Appearance White to off-white solid
CAS # 1361951-15-6
Molecular Formula C??H2??F?N?O
Molecular Weight 418.46
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)O
InChi InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)
InChi Key XRNVABDYQLHODA-UHFFFAOYSA-N
PubChem CID 66598080
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

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