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Entecavir Entecavir monohydrate Entecavir powder
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Hepatitis B virus (hepatitis B virus, HBV) infection is prevalent worldwide, but the prevalence of HBV infection varies greatly in different regions. Currently, there are 5 popular oral nucleoside (acid) analog drugs: Entecavir (ETV), Tenofovir (tenofovir, TDF), Telbivudine (LdT), Adefovir dipivoxil (adefovir, ADV), lamivudine (lamivudine, LAM). Entecavir is currently one of the first-line drugs for the antiviral treatment of patients with chronic hepatitis B recommended by the World Health Organization and national guidelines.
Entecavir, as a potent oral guanosine nucleoside analog, can selectively inhibit HBV replication. It can be phosphorylated into active triphosphates in cells and interacts with HBV reverse transcriptase natural substrate deoxyguanine triphosphate. Nucleoside competition produces drug effect. Compared with other nucleoside (acid) drugs, Entecavir has the characteristics of low incidence of resistance mutation, strongest antiviral effect and moderate price. To date, the database of the CFDA Drug Evaluation Center shows that there are more than 10 approved formulations of Entecavir.
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