- Min.Order :0 Metric Ton
- Purity: 99% up by HPLC
- Payment Terms : L/C,D/A,D/P,T/T,
Keywords
Tacrolimus FK506 104987-11-3
Quick Details
- Appearance:A white or off-white crystalline powder
- Application:1) Anti-rejection in organ transplantation 2) Treatment of skin diseases. like atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune disease
- PackAge:10g-1kg/bag
- ProductionCapacity:5000|Gram|Month
- Storage:
- Transportation:
Superiority:
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Details:
Tacrolimus
Basic information of Tacrolimus :
|
Name |
Tacrolimus (FK506) |
|
CAS : |
104987-11-3 |
|
Molecular Formula |
C44H69NO12 ·H2O |
|
Molecular Weight |
822.04 |
|
Quality Standard |
In-house Standard, Assay: >99.0% / USP36 |
|
Package Size |
Aluminium bag; Weight: Net weight 50g/bag and 100g/bag |
|
Brief Introduction |
Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. Tacrolimus is used to prevent rejection of organ transplants. Tacrolimus is 10 to 100 times superior to cyclosporin in improving graft survival and preventing acute rejection after transplantation, but decreasing the toxin side effects. |
Use of Tacrolimus :
1) Anti-rejection in organ transplantation
2) Treatment of skin diseases. like atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases
COA of Tacrolimus :
|
Tests |
Specifications |
Results |
|
Description |
A white or off-white crystalline powder |
Conform |
|
Identification |
1. IR (USP <197K>) |
Conform |
|
|
2. HPLC retention times |
Conform |
|
Water (USP <921> Method I) |
1.6 ~ 3.0% |
2.1% |
|
Residue on ignition (USP <281>) |
£ 0.2% |
0.08% |
|
Heavy metals (USP <231> II) |
£ 20 ppm |
< 20 ppm |
|
Related substances (In-house HPLC method) |
Ascomycin £ 0.8% |
0.064% |
|
|
Dihydrotacrolimus £ 0.6% |
0.089% |
|
|
Total impurities £ 1.5% |
0.15% |
|
Residual solvents (In-house method) |
Acetone £ 2000 ppm |
Not detected |
|
|
Ethanol £ 2000 ppm |
Not detected |
|
Assay (on anhydrous basis) |
98.0% ~ 102.0% |
100.0% |
|
Conclusion: Complied with In-House standard |
||
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