antineoplastic API Capecitabine Capecitabine powder CAS:154361-50-9 cas:154361-50-9 Capecitabine
1) Specialized in pharmaceutical industry since from 1987
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Company Information |
Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc..
Product Information |
Product name |
Capecitabine |
Molecular Formula |
C15H22FN3O6 |
Molecular Weight |
359.35 |
CAS No. |
154361-50-9 |
Quality Standard |
USP34, medical grade |
Appearance |
White powder |
COA of CAPECITABINE |
Items |
Specifications |
Results |
Apperance |
White or off-white crystalline powder |
White crystalline powder |
Identification |
The spectrum of the sample corresponds to that of RS |
Meets the requirements |
The retention time of the major peak of the test solution corresponds to that of the RS |
Meets the requirements |
|
Specific Rotation |
+96.0°~+100.0° |
+98.1° |
Water |
≤0.3% |
0.01% |
Heavy Metals |
≤20ppm |
<20ppm |
(as Pb) |
||
Residue on ignition |
≤0.1% |
0.02% |
Assay |
98.0%~102.0% |
99.70% |
Usage |
Function of Capecitabine
Capecitabine is rapidly absorbed through the intestinal mucosa after oral administration, and then converted into an inactive intermediate 5'-deoxy-5'fluorocytidine in the liver by carboxylesterase, and then decellularized by the liver and tumor The action of ammonia enzyme is converted into 5'-deoxy-5 'fluorouridine, and finally catalyzed by thymidine phosphorylase into fluorouracil (5-FU) in tumor tissue.
Clinical studies have shown that the concentration of 5-FU in tumor tissue after oral administration of this product is significantly higher than blood and muscle levels. The curative effect on various animal tumors is significantly higher than that of 5-FU. This product has a synergistic effect with a variety of anti-tumor drugs.
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