CasNo.738-70-5,High purity 99% factory price Trimethoprim,(738-70-5) Suppliers

1 Kilogram	FOB Price:USD 50.0000 -800.0000

Min.Order :1 Kilogram
Purity: 99% up
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

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Quick Details

Appearance:White powder
Application:As an antibacterial synergist, it can also treat poultry bacterial infection and coccidiosis.
PackAge:1kg/bag ;5kg/drum:25KG/drum
ProductionCapacity:20|Metric Ton|Month
Storage:in low tempreture
Transportation:in low tempreture

Superiority:

Why is SINOWAY:

1) Specialized in pharmaceutical and healthcare industrial for 34 years.

2) ISO 9001:2015 & SGS audited supplier .

3) Accept various payment terms : T.T 30-60 days.

4) We have warehouse in USA with quickly shipment .

5) We can do different terms of FOB ,CIF/CIP ,DDP ...

Why choose us

1. best quality in your requirement
2. competitive price in china market
3. mature technical support
4. professional logistic support
5. full experience of large numbers containers loading in chinese sea port
6. fast shipment by reputed shipping line
7. packing with pallet as buyer's special request
8. best service after shipment with email !
9. cargoes together with container after-sales service available
10. full experience in export
11. raw materials from chinese origin

Details:

Product Information

Product Name	Trimethoprim
CAS NO	738-70-5
Molecular Weight	290.318
Density	1.3±0.1 g/cm3
Boiling Point	405.2±55.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₈N₄O₃
Melting Point	199-203 °C
Flash Point	198.8±31.5 °C

Trimethoprim is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of urinary tract infections.Target: DHFRTrimethoprim (TMP), an inhibitor of dihydrofolate reductase, decreases the level of tetrahydrofolate supplying one-carbon units for biosynthesis of nucleotides, proteins, and panthotenate. TMP caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B were most efficiently induced by TMP and coaggregated with the insoluble proteins [1]. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim's affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydropteroate synthetase, an enzyme involved further upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly used in combination due to their synergistic effects. This drug combination also reduces the development of resistance that is seen when either drug is used alone [2].

Function

antibacterial drug efficiency, separate for respiratory tract infections, urinary tract infections,intestinal infections and other illnesses. Range and similar antibacterial sulfonamides, in combination with sulfa drugs or in combination with antibiotics, can significantly improve drug efficacy. For respiratory tract infections, senile chronic bronchitis, dysentery, urinary tract infection, pyelonephritis, enteritis, typhoid, gonorrhea, and some of the specific disease and other inflammation.

Cure pneogaster infection, chronic senile bronchitis, bacillary dysentery, urinary tract infection, pyelon-dphristis, enteritis typhoid, gonorrhea and some specific lesion etc