Method for extracting heparin sodium from pig small intestine

Details:

In the crude heparin industry, heparin is expensive because of its clinical value and limited channel sources. At present, it can only be extracted from the pig small intestine. Limited by the quantity, scale and quality of raw materials and crude suppliers, the price of heparin sodium has been fluctuating. After all, it is processed from animal viscera and pig small intestine. Crude product extraction, because the equipment and technical requirements are not so high (relative to heparin drug development), but the requirements of high-quality heparin sodium are much higher.

How about the extraction efficiency of heparin sodium

  How many small intestines can lift a kilogram of crude heparin with titer of 100 To think about this problem, we first need to know how much heparin can be extracted from each pig small intestine. The amount of heparin in a pig small intestine mucosa is generally about 0.5g. You can do a little more than 0.5, and it is very good that the titer is more than 100! Some pig small intestine can extract 1g heparin sodium, but the potency is low and can't sell for much. No more is of no use. He only sees a lot on the surface, but the essence shows that the technology is not qualified. The processed crude heparin sodium contains acid-base protein and impurities, which is not pure enough and has low economic benefits!

Market prospect of heparin sodium

Heparin sodium can exist in the market for so many years, and the prospect is natural. Needless to say, now the processing and extraction technology is more mature and advanced than before, with lower cost and higher profit! At present, Desheng uses the exclusive formula enzyme to make the decomposition more thorough and the output more stable! The supply of goods is sufficient and convenient. There is a reliable guarantee from the perspective of technology, equipment, raw materials, market and sales. It is a rare good project! Our company produces and sells heparin sodium all year round, with many partners at home and abroad.

Good technology is important

  Today, small workshops are replaced by large crude products factories, but small workshops can still fight alone, and there is still room for survival. It's just size. Both large and small factories and individual processing are very concerned about the extraction efficiency of small intestine. The author has communicated with the principals of some large factories and some very experienced people who have worked as individuals for a long time, which are basically in that range. In the links of hydrolysis, adsorption, elution and alcohol precipitation recovery, the more the previous links have a greater impact on the yield. In order to maximize the yield, each link must be the highest from beginning to end. You should know that even if each link is 90%, the four 90% are multiplied continuously, and there is only 65.61%.

Finally, it should be emphasized that the extraction requirements of heparin sodium must be fresh pig small intestine. The deteriorated small intestine will not only affect the potency of the product, but also reduce the yield! If the pig small intestine is red on the outside and black on the inside, it should not be preserved and deteriorated. Such pig small intestine can not be used. Desheng, as a direct manufacturer of heparin sodium, starts from the source of pig small intestine, supplemented by excellent technical conditions. At present, the potency of heparin sodium produced is 150-200iu. The higher the potency, the more expensive the price. If you are interested, welcome to consult!