Neomycin sulfate Chemical Properties |
Melting point |
>187°C (dec.) |
alpha |
D20 +54° (c = 2 in H2O) |
refractive index |
56 ° (C=10, H2O) |
Fp |
56℃ |
storage temp. |
2-8°C |
solubility |
H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days. |
form |
powder |
color |
white to slightly yellow |
PH |
5.0-7.5 (50g/l, H2O, 20℃) |
Water Solubility |
Soluble in water |
Merck |
14,6454 |
Stability: |
Stable. Incompatible with strong oxidizing agents. |
InChIKey |
OIXVKQDWLFHVGR-VTSVPHRWSA-N |
CAS DataBase Reference |
1405-10-3(CAS DataBase Reference) |
EPA Substance Registry System |
Neomycin sulfate (1405-10-3) |
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Neomycin sulfate Usage And Synthesis |
Chemical Properties |
NEOMYCIN SULFATE is white or yellowish-white powder, hygroscopic. |
Uses |
NEOMYCIN SULFATE is an aminoglycoside antibiotic found in many topical medications. NEOMYCIN SULFATE has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. |
Uses |
NEOMYCIN SULFATE is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures. |
Uses |
Neomycin sulfate is an antibiotic (can be used effectively against most bacteria that cause skin, eye and outer ear infections); broad-spectrum antibiotic in topical creams, powders, ointments, eye and ear drops; systemic antibiotic and growth promotor in veterinary use. |
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