Imatinib mesylate 220127-57-1 C30H35N7O4S
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Imatinib mesylate inhibits Bcr-Abl tyrosine kinase at the cellular level both in vitro and in vivo and selectively inhibits proliferation and induces apoptosis in fresh cells from Bcr-Abl positive cell lines, Ph chromosome-positive chronic granulocytic leukaemia and acute lymphoblastic leukaemia patients. In addition, imatinib mesylate inhibits platelet-derived growth factor (PDGF) receptor, stem cell factor (SCF), tyrosine kinase of the c-Kit receptor, thereby inhibiting cell behaviour mediated by PDGF and stem cell factor.
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