98% up by HPLC Tacr...

98% up by HPLC Tacrolimus FK-506 104987-11-3

98% up by HPLC Tacrolimus FK-506 104987-11-3

Min.Order / FOB Price:Get Latest Price

1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 98% up
  • Payment Terms : L/C,D/A,D/P,T/T

Keywords

Tacrolimus FK-506 104987-11-3

Quick Details

  • Appearance:White powder
  • Application:API anticancer
  • PackAge:1kg/bag ;25kg/drum
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:Dry place
  • Transportation:cool&dry

Superiority:

Why is SINOWAY:

1) Specialized in pharmaceutical and healthcare industrial for 34 years.

2) ISO 9001:2015 & SGS audited supplier . 

3) Accept various payment terms : T.T 30-60 days.

4) We have warehouse in USA with quickly shipment .

5) We can do different terms of FOB ,CIF/CIP ,DDP ...

Details:

Product name

Tacrolimus ; FK-506

CAS No.

104987-11-3

Molecular Formula

C44H69NO12

Molecular Weight

804.02

Quality Standard

98% up by HPLC

Appearance

White or light yellow powder

 

  Items

Specifications

Results

Appearance

White or light yellow powder

White or light yellow powder

Assay

98%-102%

99.1%

Water

≤ 3.0%

2.5%

Related substances

Ascomycin ≤ 0.8%

0.05%

Dihydrotacrolimus ≤ 0.6%

0.3%

Total Impurities ≤ 1.5%

0.43%

Residual solvents

Acetone ≤ 2000ppm

ND

Ethanol ≤ 2000ppm

ND

Heavy metals

≤ 20ppm

< 20ppm

Single impurity

≤ 0.6%

0.2805%

Total impurity

≤ 1.5%

0.33%

Conclusion

Meet the specifications

 

Function of Tacrolimus

 

Tacrolimus (FK506), a macrolide, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase (calcineurin phosphatase), thereby inhibiting T lymphocyte signal transduction and IL-2 transcription, with strong Immunosuppressive properties. In recent years, as a first-line drug for liver and kidney transplantation, it has been marketed in 14 countries including Japan and the United States. Clinical experiments show that it has a good effect in transplantation of heart, lung, intestine, bone marrow, etc. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases.

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