factory supply GMP,DMF Sulfadoxine

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1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: USP/EP/BP
Payment Terms : L/C,T/T,Other

Keywords

Sulfadoxine BENZENESULFONAMIDE 1405-10-3

Quick Details

Appearance:White crystallization
Application:Antibiotics
PackAge:25kg/drum
ProductionCapacity:10|Metric Ton|Day
Storage:room temperature
Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Sulfadoxine.Our mfr is GMP certified for this item with CEP document.

Product Name:	Sulfadoxine
Synonyms:	4-amino-n-(5,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamid;6-(4-aminobenzenesulfonamido)-4,5-dimethoxypyrimidine;fanasil;sulforthomidine;6-(4-aminobenzenesulfonamide)-4,5-dimethoxypyrimidine;4-sulfanilamido-5,6-dimethoxypyrimidine;4-AMINO-N-(5,6-DIMETHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE;Sulfadoxine
CAS:	2447-57-6
MF:	C12H14N4O4S
MW:	310.33
EINECS:	219-504-9
Mol File:	2447-57-6.mol

Details:

Sulfadoxine Usage And Synthesis

Pharmacology and mechanism of action

The efficacy of sulphadoxine for the treatment of human malaria was first reported in 1964 ^[1]. Soon thereafter it was found that potentiation took place when sulphadoxine was combined with pyrimethamine for treatment of malaria and monotherapy was abandoned.
Malaria parasites synthesize their folate co-factors and cannot use dietary folic acid as the human host can. Sulphadoxine competes with para-aminobenzoic acid (PABA) for binding to the enzyme dihydropteroate synthetase in the synthesis of dihydropteroate which is an essential substance for the formation of folic acid^[2]. It is active against asexual blood forms of P. falciparum but less active against other species. The action is too slow to be used alone for malaria treatment ^[3].

Indications

Sulphadoxine is used only in combination with pyrimethamine for the treatment of falciparum malaria. It should generally not be used for malaria prophylaxis except perhaps in long-term travellers who have previously tolerated the combination.