factory supply GMP,DMF Posaconazole

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: USP/EP/BP
Payment Terms : L/C,T/T,Other

Keywords

Posaconazole itraconazole 124750-99-8

Quick Details

Appearance:White crystallization
Application:antifungal.
PackAge:25kg/drum
ProductionCapacity:10|Metric Ton|Day
Storage:room temperature
Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Posaconazole.Our mfr is GMP certified for this item with DMF document.

Product Name:	Posaconazole
CAS:	171228-49-2
MF:	C37H42F2N8O4
MW:	700.78
EINECS:	682-747-8
Product Categories:	API;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
Mol File:	171228-49-2.mol

Details:

Posaconazole Usage And Synthesis

Pharmacological effects

Posaconazole (posaconazole) is derived from itraconazole. It is currently subject to III phase clinical trials. Its pharmacological effects are similar with azoles, but compared with itraconazole, it has a stronger inhibitory effect on the C14 demethylation of steroid, especially for Aspergillus.

Pharmacokinetics

Studies on dosage and dosage protocol have shown that the rate of absorption and elimination rate is in line with the single-compartment model. There are significant differences on the relative bioavailability of different doses of oral suspension. It can be taken separately (every 12 hours or every 6 hours) which can significantly improve the bioavailability with the protein binding rate of 98% to 99%. With respect to tablets, the bioavailability of suspensions increase and food can significantly improve the speed and extent of absorption of drug absorption. An investigation of renal dysfunction on the pharmacokinetics of the drug study results has showed that the drug can’t be removed by hemodialysis without being affected by hemodialysis. Single-dose study has showed that patients with varying degrees of chronic kidney disease have no necessity for dosage adjustment. The Half-life of this is about 25 hours which can be primarily metabolized by the liver.