factory supply Nebivolol hydrochloride

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1 Kilogram	Negotiable

1 Kilogram

Negotiable

Nebivolol hydrochloride Nebivolol 152520-56-4

We are very compeitive on Nebivolol hydrochloride.Our mfr is GMP certified for this item with CEP document.

Product Name:	Nebivolol hydrochloride
CAS:	152520-56-4
MF:	C22H26ClF2NO4
MW:	441.8959464
EINECS:	1806241-263-5
Product Categories:	R-67145;API;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	152520-56-4.mol

Nebivolol hydrochloride Usage And Synthesis

Chemical Properties	White to Off-White Powder
Uses	A -Adrenergic blocker. Used as an antihypertensive
Uses	Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM
Biological Activity	Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo