GMP certificated Gr...

GMP certificated Granisetron HCL with EP standard

GMP certificated Granisetron HCL with EP standard

Min.Order / FOB Price:Get Latest Price

10 Gram

Negotiable

  • Min.Order :10 Gram
  • Purity: ?97.0%-102.0% by HPLC
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

97% up by HPLC Granisetron HCL CAS:107007-99-8 Granisetron HCL CAS:107007-99-8

Quick Details

  • Appearance:White or almost white powder
  • Application:an antiemetic drug, mainly suitable for nausea and vomiting caused by radiotherapy, cytotoxic drug chemotherapy, and surgery.
  • PackAge:100g/bag or per customer's requirement
  • ProductionCapacity:10|Kilogram|Month
  • Storage:
  • Transportation:

Superiority:

1) Specialized in pharmaceutical industry since from 1987

2) ISO 9001:2015 & SGS audited supplier 

3) Accept better payment terms : T.T 30-60 days.on the basic of pass SINOSURE credit investigation.

5) We have warehouse in USA with quickly shipment .

6) We can do different terms of FOB ,CIF/CIP ,DDP ...

Details:

Company Information

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc..

Product Information

Product name

Granisetron Hydrochloride

CAS No.

107007-99-8

Molecular Formula

C18H21D3N4O

Molecular Weight

348.87

Quality Standard

97% up by HPLC

Appearance

White powder

 

COA of Granisetron Hydrochloride

  Items

Specifications

Results

Appearance

White or almost white powder

White powder

 

Identification

IR spectrum: Simple IR spectrum comparable with that of the standard

Conforms

Chloride: Positive

Conforms

Solubility

Freely soluble in water，sparingly soluble in methanol very slightly soluble in methylene chloride.

Conforms

Appearance of solution

Clear and colourless

Conforms

pH

4.0-6.5

5.88

Impurity E(by TLC)

NMT 0.5%

< 0.5%

Loss on drying

NMT 0.5%

0.05%

Sulphated ash

NMT 0.1%

0.02%

 

 

 

 

Related substances

 2-methyl-N-[(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]non-3- yl]-2H-indazole-3 carboxamide (Impurity A): NMT 1.0%

ND

N-[(1R,3r,5S)-9-methyI-9-azabicyclo[3.3.1]non-3-yI]-1H-in dazole-3 carboxamide (Impurity B): NMT 0.5%

ND

N-[(1R,3r,5S)-9-azabicyclo[3.3.1]non-3-yl]-1-methyl-1H-in dazole-3 carboxamide ( Impurity C):NMT 0.2%

0.01%

1-methyI- 1H-indazole-3- carboxylic acid ( Impurity D) : NMT0.1%

ND

Any other impurity: NMT 0.10%

99.26%

Total impurities: NMT 1.0%

0.01%

Residual solvents

Ethanol: NMT 1000ppm

280ppm

Isopropanol: NMT1000ppm

ND

Dichloromethane

ND

 Assay by HPLC

 97.0%-102.0% (dried basis)

100.0%

 Endotoxins

 NMT 125 EU/mg

< 125 EU/m

Microbial limits

Total aerobic microbial count: NMT 100CFU/g

Conforms

Absence of S. aureus, E.Coli, P.aeruginosa, Salmonelia apecies

Conforms

Conclusion

Meet the EP9.0 specifications

 

Usage

Function of Granisetron Hydrochloride

Granisetron hydrochloride is an antiemetic drug, mainly suitable for nausea and vomiting caused by radiotherapy, cytotoxic drug chemotherapy, and surgery. It has a better preventive and therapeutic effect. The mechanism of controlling nausea and vomiting is mainly through antagonism Central chemoreceptors and related receptors of neurotransmitters in the peripheral nervous system can inhibit the occurrence of nausea and vomiting. The selectivity of drug treatment is relatively high, and the adverse reactions to the central nervous system are relatively few. Less cause excessive sedation and other adverse reactions.

 

Granisetron hydrochloride is also used for surgical prevention. Generally, it only needs to be administered once. The preventive effect on nausea and vomiting can be more than 24 hours, so the effect time is relatively long. When using it, you need to pay attention to the gastrointestinal tract. Patients with obstruction are contraindicated.

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