Effect of potassium EDTA on biochemical test items

Details:

EDTA dipotassium is an anticoagulant often added in blood collection vessels in clinic, and it is mostly used in blood routine test items. So is it applicable to biochemical testing projects Today, let's talk about common biochemical examination items and the impact of potassium EDTA on them.

Biochemical examination items have many indicators, such as liver function examination, renal function examination, myocardial enzyme examination, blood lipid and blood glucose examination. These examinations seem to have little relationship with EDTA dipotassium, but they also add raw materials such as chromogen substrate and enzyme preparation. EDTA dipotassium products are required for separate blood hemoglobin examination and whole blood examination.

In clinical biochemical examination items, if EDTA dipotassium blood collection anticoagulant tube is used for biochemical examination, high potassium, low calcium, low magnesium, low ALP and other effects will occur. Why do you say that They are listed as follows:

1. Potassium EDTA itself contains potassium ions, resulting in high blood potassium.

2. EDTA can chelate calcium ions in blood samples, resulting in low calcium.

3. EDTA chelates magnesium ions in blood samples, resulting in the decrease of blood magnesium. Note: in addition to calcium ions and magnesium ions, EDTA also chelates other divalent metal ions, such as manganese ions, iron ions, etc.

4. Magnesium ion is the activator of ALP activation center, so dipotassium EDTA will also reduce the activity of ALP.

In conclusion, due to the penetration and dilution of potassium EDTA, it may have an uncertain impact on the data accuracy of biochemical examination items. In order to avoid these effects, the correct anticoagulant should be selected in different tests. Desheng biochemical R & D and production of various blood collection anticoagulants, including heparin, sodium potassium EDTA, potassium oxalate, trisodium citrate, etc. Contact Desheng if necessary, and the sales manager will recommend appropriate anticoagulants to you according to your needs. As the new year is approaching, customers in need should prepare the goods as soon as possible.