Role of HEPES buffer in medical field

Details:

Hepes full name 4 - (2-hydroxyethyl) piperazine-1-ethanesulfonic acid is a buffer that can be used for radiolabeling gallium 68 compounds. The beneficial effect of HEPES on molar activity in biological conjugates has been well described, and the content of HEPES in radiopharmaceuticals is strictly regulated, which limits its use.

Radioactive synthesis of gallium 68 compounds usually requires a labeled mixture with a pH of 3.5-5.0 to ensure a good coordination between gallium 68 and precursors. Buffers such as 4 - (2-hydroxyethyl) piperazine-1-ethanesulfonic acid (HEPES) and sodium acetate are widely used to label radiopharmaceuticals with 68 gallium. According to the literature, these buffers have low metal complexation characteristics, making them suitable for adjusting pH value and reducing colloid formation during labeling.

It is found by reference that adjusting pH with HEPES during radioactive labeling with 68 gallium provides Zui good results in molecular activity, repeatability, reliability and versatility. The European Pharmacopoeia specifies a HEPES content of 200 per dose of radiopharmaceuticals for intravenous administration μ G is strictly limited. However, the method for testing HEPES in radiopharmaceutical preparations described in the European Pharmacopoeia has proved to be unreliable. Despite its excellent buffering performance, its lower limit limits the use of HEPES in 68 gallium radiopharmaceuticals. The lack of toxicological data, especially after intravenous administration, is generally considered to be the main reason for these strict restrictions.

To sum up, HEPES buffer is widely used in the medical field, but due to some reasons, there are some restrictions on its use, so that its role in this field cannot be brought into full play. HEPES buffer has strict requirements for its specifications in some fields, and our company is a manufacturer specializing in the production of biological buffer "Hubei xindesheng Material Co., Ltd.".

As a manufacturer specializing in the production of biological buffers, Desheng company provides a large number of high-quality HEPES and many other types of biological buffers. We can customize the product specifications and provide after-sales service according to customer needs, and we can provide professional testing services and packaging customization services to special customers. In any case, Desheng company must be your best choice to buy biological buffer.