What are the applications of luminol luminescent system in drug analysis?

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Luminol can be oxidized by many substances to produce chemiluminescence. It is an early and widely used luminescent reagent. The chemiluminescence analysis of metal ions plays an important role in the research and application of chemiluminescence analysis. Some metal ions can enhance the chemiluminescence of luminol system; - Some ions can inhibit the chemiluminescence of luminol system; Some ions can directly oxidize luminol to produce chemiluminescence. In our drug analysis, we use the catalysis or inhibition of metal ions and compounds for direct or indirect detection. Let's take a look at how luminol is "out of line" in drug analysis.

Application of luminol luminescent system in drug analysis

1. Use the catalysis or inhibition of metal ions and metal ion compounds for direct or indirect detection, such as the determination of sodium nitroprusside (SNP) and catechols. Some reducing substances such as citric acid, citrate, VC and ascorbic acid can also be detected by metal ion luminol luminescence system.

2. Enhancement or inhibition of luminol chemiluminescence reaction by biomolecules and organics. The chemiluminescence detection methods of albumin and uric acid were established. Ascorbic acid can be determined by the inhibition of ascorbic acid on Luminol-K3Fe (CN) 6 system in alkaline medium. Luminol-K3Fe (CN) 6 system can also be used to monitor glucose and lactic acid. Mercaptan containing drugs and promethazine can inhibit luminol luminescence system. Therefore, a detection method is proposed.

3. Preparation of consumable chemiluminescence sensor. Luminol and other reagents were fixed on ion exchange resin, and a chemiluminescence flow injection sensor was developed and used for the determination of VC. The enzyme immobilized column is combined with FIA, and the immobilized enzyme reactor is used for luminol luminescence detection. It has been used for the detection of glucose, alcohol, oxalate, lactate, choline, uric acid in serum and urine.

Seeing the strength of Lumino, we suddenly found that it was acceptable everywhere. This also fully shows its value. If you want to know more about luminol and its use, you might as well find its manufacturer - Desheng. I'm sure you'll ask.