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Artesunate 88495-63-0 Artemisia annua extract
Artesunate is a rapid insecticide against Plasmodium falciparum in the erythrocytic stage of Plasmodium falciparum. It can quickly control the acute attack of malaria after taking it. it is used for the rescue of dangerous malaria such as brain type, jaundice type and the treatment of falciparum malaria.
Artesunate is a commonly used antiparasitic drug, which is a derivative of artemisinin with sesquiterpene lactone structure to reduce artemisinin succinate. it has a stronger effect on Plasmodium than artemisinin and is effective against chloroquine strains. Acting on the erythrocytic merozoite of Plasmodium Chemicalbook, artemisinin inhibits cytochrome oxidase by reducing artemisinin to inhibit the cytochrome oxidase of plasmodium surface membrane-food vesicle and mitochondrial membrane, thus blocking the supply of host cytoplasm as nutrition.
Chemical Name: Artesunate
CAS No.: 88495-63-0
Chemical Structure: C19H28O8
Molecular weight: 384.42
Appearance: white powder
Assay: 98%min
Artemisia Annua Extract Powder also known as Qinghaosu (Chinese), and its derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria.Treatments containing an artemisinin derivative (artemisinin-combination therapies, ACTs) are now standard treatment worldwide for P. falciparum malaria. The starting compound artemisinin is isolated from the plant Artemisia annua, sweet wormwood, an herb employed in Chinese traditional medicine.
Chemically, artemisinin is a sesquiterpene lactone containing an unusual peroxide bridge. This peroxide is believed to be responsible for the drug's mechanism of action. Few other natural compounds with such a peroxide bridge are known.(Ascaridole isanother.)
Use of the drug by itself as a monotherapy is explicitly discouraged by the World Health Organization, as there have been signs that malarial parasites are developing resistance to the drug. Therapies that combine artemisinin with some other antimalarial drug are the preferred treatment for malaria and are both effective and well tolerated in patients. The drug is also increasingly being used in Plasmodium vivax malaria,[3] as well as being a topic of research in cancer treatment.
1. It has a strong killing effect on the asexual body of Plasmodium, and can quickly control the outbreak of malaria.
2.Antimalarial drug.
3. Artesunate is a semisynthetic artemisinin derivative that has been shown to be effective against parasites such as liver fluke (liver flukes) and has cytotoxic effects on different types of tumor cell lines.
Item |
Specification |
Analytical Result |
Apperance |
White crystalline powder,odorless |
Conforms |
Solubility |
Free soluble in ethanol,acetone or chloroform,very slightly solyble in water |
Conforms |
Specific optical rotation |
+4.5°~6.5° |
+5.3° |
Identification |
|
|
TLC |
The pronciopal spot in the chromatogram obtained with the test solution is similar in posotion,colour to the principal spot in the chromatogram obtained the reference solution |
Conforms |
HPLC |
The retention time of main peak of test and standard are concordant |
Conforms |
IR |
Infrared absorption spectrum of test and standard(or infrared reference spectra No.221) are concordant |
Conforms |
Tests |
|
|
Acidity |
3.5-4.5 |
4.3 |
Apperance of solution |
Solution S is clear and not more intensely colored than reference solution 1 |
Conforms |
Chlorieds |
Not more than pronounced (0.02%) |
Conforms |
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