CasNo.37905-08-1,Supply Artichoke extract jolkinolide B 98%,(37905-08-1) Suppliers

1 Gram	Negotiable

Min.Order :1 Gram
Purity: 98%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

jolkinolide B 37905-08-1 Artichoke extract

Quick Details

Appearance:White powder
Application:Scientific research reagent
PackAge:25kg / cardboard barrel
ProductionCapacity:1|Metric Ton|Month
Storage:Sealed in dry,Room Temperature
Transportation: Express, air cargo and sea

Superiority:

With the increase of berberine B concentration, it can significantly inhibit the proliferation of MDA-MB-231 cells and block G1 cells. Compared with the blank group, 20-40 μ The mRNA expression of CyclinD1 and eIF4E was inhibited by mol-1 Euphorbia lactone B. the mRNA expression and protein level of cyclindchemicalbook1 in the transfected eIF4E siRNA group were also inhibited, and the cell cycle was blocked in G1 phase (P < 001, P < 0.01). Therefore, hallido B can inhibit the proliferation of human breast cancer cells and arrest the cell cycle in G1 phase. It may be due to its inhibition of eIF4E expression and the downregulation of CyclinD1 expression.

Details:

Chemical Name: jolkinolide B
CAS No.: 37905-08-1

Chemical Structure: C20H26O4

Molecular weight: 330.42

Appearance: White powder

Assay: 98%min

1. Jolkinolide B (JB) is the main component of Euphorbia chamaejasme. It was first published in Shennong herbal classic. Its root is used as medicine and toxic. It is used in the folk to treat skin, tuberculosis, tumor and other diseases. Diterpenoids separated from roots of Euphorbia Fischer root. Chemicalbook ester B from 17- hydroxyl rock Euphorbia Fischer can inhibit K562 cell growth and induce apoptosis in vitro, and find that it has a significant anti-inflammatory effect. In addition, studies have shown that it can induce apoptosis of MDA-MB-231 cells through inhibiting PI3K/Akt signaling pathway. It can be used in the treatment of malignant tumors.

1.Scientific research reagent，

Appearance	White wax powder	Conforms
Odor	Characteristic	Conforms
Tasted	Characteristic	Conforms
Assay(Octacosanol)	98% Min	98.73%
Sieve Analysis	100% pass 60 mesh	Conforms
Loss on Drying	5% Max.	3.17%
Sulphated Ash	5% Max.	3.36%
Extract Solvent	Alcohol & Water	Conforms
Heavy Metal	5ppm Max	Conforms
As	2ppm Max	Conforms
Residual Solvents	0.05% Max.	Negative
Microbiology
Total Plate Count	10000/g Max	Conforms
Yeast & Mold	100/g Max	Conforms
E.Coli	Negative	Conforms
Salmonella	Negative	Conforms