Nilotinib 641571-10-0 Nilotinib 641571-10-0
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Product name |
Nilotinib |
CAS No. |
641571-10-0 |
Molecular Formula |
C28H22F3N7O |
Molecular Weight |
529.523 |
Quality Standard |
99% up by HPLC |
Appearance |
White to pale yellow powder |
Function of Nilotinib
Nilotinib is improved from the molecular structure of imatinib, and has stronger selectivity for BCR-ABL kinase activity, and its inhibitory effect on tyrosine kinase is 30 times stronger than that of imatinib, which can inhibit Kinase activity of imatinib-resistant BCR-ABL mutants, while also inhibiting KIT and PDGFR kinase activities. For the treatment of chronic myeloid leukemia (CML), a life-threatening blood cancer that is refractory to or intolerable to imatinib mesylate. Based on a pivotal Phase II clinical study design evaluating the positive results of oral nilotinib in clinical trials against imatinib mesylate or in patients with Ph+ CML in the slow and accelerated phases of apparent toxicity: High efficacy, good tolerance, and manageable safety.
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