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China Biggest factory manufacturer supply Pomegranate Peel Extract (Ellagic Acid) CAS476-66-4

China Biggest factory manufacturer supply Pomegranate Peel Extract (Ellagic Acid) CAS476-66-4

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50 Kilogram

FOB Price:USD 45.0000 -50.0000

  • Min.Order :50 Kilogram
  • Purity: 40%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Pomegranate Peel Extract Ellagic Acid 476-66-4

Quick Details

  • Appearance:brown powder
  • Application:hemostatic, antineoplastic, antimutagenic
  • PackAge:25KG/Drum
  • ProductionCapacity:50|Metric Ton|Month
  • Storage:2-8°C
  • Transportation:By air /Sea/ coruier

Superiority:

Ellagic acid Basic information
Product Name: Ellagic acid
Synonyms: eleagicacid;gallogen(astringent);lagistase;TIMTEC-BB SBB006501;2,3,7,8-tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione;ELLAGIC ACID;BENZOARIC ACID;AKOS NCG1-0028
CAS: 476-66-4
MF: C14H6O8
MW: 302.19
EINECS: 207-508-3
Product Categories: Anthraquinones, Hydroquinones and Quinones;Natural Plant Extract;Antioxidant;Biochemistry;plant extract;Inhibitors;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Building block;Food additive;Plant extracts
Mol File: 476-66-4.mol
Ellagic acid Structure
 
Ellagic acid Chemical Properties
Melting point  ≥350 °C
Boiling point  363.24°C (rough estimate)
density  1.667
refractive index  1.5800 (estimate)
storage temp.  2-8°C
solubility  1 M NaOH: 10 mg/mL, dark green
form  powder
color  tan to gray
Water Solubility  <0.1 g/100 mL at 21 ºC
Sensitive  Air & Light Sensitive
Merck  14,3547
BRN  47549
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey AFSDNFLWKVMVRB-UHFFFAOYSA-N
CAS DataBase Reference 476-66-4(CAS DataBase Reference)
EPA Substance Registry System Ellagic acid (476-66-4)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-36/37
WGK Germany  3
RTECS  DJ2620000
8-10-23
HS Code  29322090
Hazardous Substances Data 476-66-4(Hazardous Substances Data)
Toxicity LD50 oral in rat: > 20gm/kg

Details:

Ellagic acid Usage And Synthesis
Chemical Properties cream to light yellow crystalline solid
Uses hemostatic, antineoplastic, antimutagenic
Uses Ellagic Acid is a phenol antioxidant found naturally in various fruits and vegetables. Ellagic Acid was shown to exhibit high levels of antiproliferative and antioxidant properties in studies, which s uggests its potential health benefits following ellagic acid consumption.
Uses Ellagic acid used as selective, ATP-competitive inhibitor of casein kinase 2. Exhibits antitumor activity and inhibits glutathione S-transferase. It is also used as a Topo I and II, FGR, GSK, and PKA inhibitor.Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma.Contact activation in blood coagulation.
Definition ChEBI: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, ncluding raspberries, strawberries, cranberries, and pomegranates.
General Description Cream-colored needles (from pyridine) or yellow powder. Odorless.
Air & Water Reactions Insoluble in water.
Reactivity Profile Ellagic acid reacts as a weak acid. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated. Heat is also generated by the acid-base reaction between phenols and bases. May be sulfonated exothermically very readily (for example, by concentrated sulfuric acid at room temperature). May be nitrated very rapidly, even by dilute nitric acid.
Fire Hazard Flash point data for Ellagic acid are not available; however, Ellagic acid is probably combustible.
Biological Activity Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC 50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase.
Biochem/physiol Actions Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase. Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation.
Anticancer Research Ellagic acid is a naturally occurring phenolic constituent present in natural productsand nuts, most elevated amounts of which are found in raspberries (Daniel et al.1990). EA is considered as a potent anticarcinogenic and antimutagenic compound.EA shows anti-angiogenic property by repressing PDGF-R movement and phosphorylationof its substrate. It can intrude with endothelial cell-associated VEGR-2phosphorylation bringing about the restraint of the downstream signaling activatedby this receptor and in the hindrance of two key events fundamental in angiogenesis,i.e., EC movement and morphogenic separation into capillary-like structure. In parallel,EA indicated robust inhibitory activity against perivascular cells through itsrestraint of PDGF-R action and signaling prompting hindrance of VSMC relocation(Labrecque et al. 2005).
It is a phenolic compound extracted from pomegranate. It is an antiproliferative andantioxidant compound (Murakami et al. 1996). It induces apoptosis in cancer cellsof the prostate and breast and prevents the process of metastasis in different cancers(Singh et al. 2016b).
Purification Methods This antioxidant crystallises from pyridine. It forms a dark green solution in aqueous N NaOH. The tetraactetate dilactone crystallises from Ac2O, with m 340o. [Beilstein 19 H 261, 19 III/IV 3164, 19/7 V 108.]

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