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factory supply GMP,DMF,CEP Aminophylline
factory supply GMP,DMF,CEP Aminophylline
factory supply GMP,DMF,CEP Aminophylline
factory supply GMP,DMF,CEP Aminophylline

factory supply GMP,DMF,CEP Aminophylline

Min.Order / FOB Price:Get Latest Price

1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: USP/EP/BP
  • Payment Terms : L/C,T/T,Other

Keywords

Aminophylline Aminophylline 317-34-0 317-34-0

Quick Details

  • Appearance:White crystallization
  • Application:Cardiovascular APIs,Sartan antihypertensive drugs
  • PackAge:25kg/drum
  • ProductionCapacity:10|Metric Ton|Day
  • Storage:room temperature
  • Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Aminophylline.Our mfr is GMP certified for this item with CEP document. 

Product Name: Aminophylline
CAS: 317-34-0
MF: C9H16N6O2
MW: 240.27
EINECS: 206-264-5
Product Categories: Somopphyllin, Aminocadol, Phyllocontin;Miscellaneous Biochemicals;API's;317-34-0
Mol File: 317-34-0.mol
Aminophylline Structure

Details:

Aminophylline Usage And Synthesis
Description Aminophylline is a drug combination consisting of bronchodilator theophylline and ethylenediamine in 2: 1 ratio. It is a kind of non-selective adenosine receptor blocker, histone deacetylase activator and phosphodiesterase inhibition. It is mainly indicated for the treatment of various kinds of lung diseases including asthma, COPD, chronic bronchitis and emphysema. Aminophylline exerts its effect through the component of theophylline in vivo. Theophylline can relax the smooth muscle of the bronchial airways and pulmonary blood vessels. It can competitively inhibits type III and type IV phosphodiesterase (PDE), which breaks down cyclic AMP in smooth muscle cells, possibly leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor to block the adenosine mediated bronchoconstriction. Furthermore, during the inflammatory states, theophylline can activate the histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones to initiate the transcription.
References # #
Description Aminophylline is a 2/1 mixture of theophylline and ethylenediamine. It caused contact dermatitis in industrial plants, in pharmacists, and in nurses. Ethylenediamine is the sensitizer, and patch testing is generally positive to both ethylenediamine and aminophylline, but negative to theophylline.
Chemical Properties white to slightly yellowish powder
Originator Memcophylline,Memphis Co.
Uses Aminophylline exhibits vasodilatory and anti-inflammatory activity and is occasionally clinically used to treat chronic obstructive pulmonary disorder (COPD). In animal models of allergen-induced lung inflammation, aminophylline decreases levels of IL-5, IL-8, and eosinophils. It is mostly used to prepare solutions for intravenous injections.
Uses Bronchodilatator;Mastocytes degranulation inhibitor
Uses Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.
 

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