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Hydroxypropyl beta cyclodextrin Hydroxypropyl Hydroxypropyl cyclodextrin
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【Product name】Hydroxypyle beta cyclodextrin
【Synonyms】
HPBCD
HP-beta-cyclodextrin
Hydroxyethyl-β-Cyclodextrin
HYDROXYPROPYL-SS-CYCLODEXTRIN
HYDROXYPROPYL-BETA-CYCLODEXTRIN
2-Hydroxypropy-beta-cyclodextrin
beta-Cyclodextrin 2-hydroxypropyl ethers
【CAS No.】 94035-02-6
【Mol. Formula】 (C42H70-nO35) (C3H7O) n
【Mol. Weight】1375.36
【Standard】Medicine grade(EP8.0)/Food grade
【Assay】≥99.0%
【Appearance】White powder
【Appearance of solution】Clear and colourless
【Packing】25kgs/drum (standard packing)
【Storage】Store at (2~8℃) temperature. Protect from moisture
Hydroxypropyl beta cyclodextrin: Hydroxypropyl betadex are purified polydisperse products resulting from the controlled reaction of propylene oxide and native beta-cyclodextrin. Hydroxypropyl beta cyclodextrin is itself very soluble in water (greater than 500 mg/ml at room temperature compared to 18 mg/ml for beta-cyclodextrin), and is used for molecular encapsulation of a variety of sparingly water compounds to enhance the aqueous solubility of the encapsulated compound.
Hydroxypropyl Beta Cyclodextrin (HPBCD) is an ideal injectable solubilizer and pharmaceutical excipient. the main functions: olubilizing poorly soluble drugs, adjust or control the release rate of the drug to reduce the toxic and side effects of the drug.
Quality Standard
Item |
Specifications |
Purity |
>98.0% |
Solubility |
>75.0g/100ml |
Identification A B |
Complies with the tests |
Specific rotation |
+128.0~+145.0° |
Acidity & AIKalinity pH |
5.0~8.0 |
Loss on drying |
<5.0% |
Residue on ignited |
<0.5% |
Chloride |
<0.018% |
Heavy metal(Pb) |
≤20ppm |
Arsenic |
<4ppm |
Conductivity |
≤200 uS·cm-1 |
Molar substitution |
0.4-1.5 |
Microbial contamination Bacteria Fungi Escherichia coli Salmonella |
≤300 cfu/g ≤100 cfu/g None detected None detected |
Bacterial endotoxins |
≤10 IU/g |
Appearance of solution |
Clear and colourless |
Appearance |
White powder |
Application
1) In food manufacturing
Hydroxypropyl Beta Cyclodextrin is mainly used to eliminate peculiar smell, improve the stability of flavor essence and pigment, enhance emulsification ability and moisture-proof ability.Improving the taste of food is a good stabilizer and charming agent for pharmaceutical food and cosmetics manufacturing industry.
2) In medicine
Hydroxypropyl Beta Cyclodextrin can improve the solubility and bioavailability of drugs, increase the efficacy or decrease the dosage of drugs, adjust or control the release rate of drugs, reduce the toxic and side effects of drugs, and enhance the stability of drugs. It is mainly used in oral liquid with the highest safety.
3) Household chemicals
As a stabilizer, emulsifier and scent masking agent, hydroxypropyl β-cyclodextrin can minimize the irritation to skin and mucous membranes resulting from the organic molecules in cosmetics. Additionally, it enhances the stability of active ingredients, protects nutrients against vaporization and oxidation, solubilizes insoluble fragrance and sustains the release of the fragrance to keep it long-lasting.
4) Other sectors
Hydroxypropyl β-cyclodextrin has been widely used in many sectors including coating and painting products, tobacco products, pesticide excipients, plant growth regulators for agricultural use, paper industry, textile industry, et al. As people are gaining great awareness of hydroxypropyl β-cyclodextrin, it shows great promise and is used in more and more fields.
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