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factory supply DMF Lestaurtinib
factory supply DMF Lestaurtinib
factory supply DMF Lestaurtinib
factory supply DMF Lestaurtinib

factory supply DMF Lestaurtinib

Min.Order / FOB Price:Get Latest Price

1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: USP/EP/BP
  • Payment Terms : L/C,T/T,Other

Keywords

Lestaurtinib KT-5555 3562-99-0

Quick Details

  • Appearance:White crystallization
  • Application:Stimulating gastro-intestinal function
  • PackAge:25kg/drum
  • ProductionCapacity:10|Metric Ton|Day
  • Storage:room temperature
  • Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Lestaurtinib.Our mfr with DMF document. 

Product Name: Lestaurtinib
Synonyms: Lestaurtinib (KT-5555;CS-1165;lestaurtinib;(9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one;SPM-924;CEP-701 hydrate;KT-5555 hydrate;Lestaurtinib hydrate
CAS: 111358-88-4
MF: C26H21N3O4
MW: 439.47
EINECS:  
Product Categories: Inhibitor;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 111358-88-4.mol
Lestaurtinib Structure

Details:

Description Lestaurtinib (111358-88-4) is a potent and selective FLT3 inhibitor (IC50= 2 nM).1,2 Inhibits RET and RET phosphorylation in medullary thyroid carcinoma cells.3 Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.4 Potent Trk inhibitor.5 Cell permeable.
Chemical Properties Lestaurtinib is Off-White Solid
Uses Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)
Uses It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).
Uses CEP-701 hydrate has been used as a tyrosine kinase inhibitor:
  • to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells
  • as a supplement in reservoir solution for co-crystallization studies with human receptor-interacting protein kinase 4 (RIPK4)
  • as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia

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