3,3'-Diindolylmethane

Superiority:

Melting point: 167 ° C

Boiling point: 230 ° C (Press: 0.01Torr)

Density: 1.271 ± 0.06g/cm3 (Predicted)

Storage conditions: 2-8 ° C

Solubility: Chloroform (Sparingly), Methanol (Slightly)

Acidity coefficient (pKa): 16.91 ± 0.30 (Predicted)

Form: Off whitepowder

Color: WhitetoPaleBeige

LogP: 4.401 (est)

CAS Database: 1968-05-4 (CASDataBaseReference)

troduction: 3,3 '- Diindoylmethane is a white to almost white crystalline powder that is soluble in organic solvents such as methanol, ethyl acetate, and dichloromethane.

Application: 3,3 '- diindolylmethane is widely present in natural plants of the Cruciferae family. It has important biological and pharmacological activities and is widely used in the fields of medicine and health products.

Preparation: Place indole (1.17g, 10mmol), CTAB (50% mol), and oxalic acid (50% mol) in a 25ml single ended circular bottom flask, add 5ml of deionized water, stir thoroughly for 5 minutes, and then add a dropwise solution of formaldehyde (0.38g solution, 5mmol formaldehyde). React at room temperature for 3 hours and stop the reaction. Extract the reaction solution three times with 5 ml of ethyl acetate in 1 Chemicalbook, collect the organic phase, and dry it with anhydrous Na2SO4 for 5 hours. Remove the solvent under reduced pressure and recrystallize with a mixed solution of methanol and water (methanol/H2O=10/1) to obtain a white solid 3,3 '- diindolylmethane in a yield of 85%.

Bioactive 3,3 '- Diindolylmethane (DIM) is the main digestive product of indole-3-carbinol, which is a potential anticancer substance in cruciferous vegetables. 3,3 '- Diindolylmethone (DIM) is a strong antagonist of pure androgen receptor (AR).