Indole-3-carbinol

Superiority:

Factory spot supply of high-quality 99% 3-indole methanol

[English Name]: 3-indolylcarbinol

[Alternative Name]: Indole-3-Methanol

Chemical formula: C9H9NO

Molecular weight: 147.17

CAS login number: 700-06-1

[English alias]: Indole-3 carbinol

Purity: 98%

[CAS Number]: 700-06-1

[Detection Method]: HPLC

Overview: Currently, there are many anti-tumor drugs, but ideal, efficient, and low toxicity anti-tumor drugs have not yet been found. Therefore, researching efficient, low toxicity, and even natural anti-tumor drugs to enrich the prevention and treatment methods of laryngeal cancer has become a hot topic and focus of research by many experts and scholars. Chemicalbook indole-3-carbinol is a tumor chemopreventive substance that can be extracted from cruciferous vegetables such as broccoli, radish, and cauliflower. Indole-3-methanol can inhibit the occurrence and development of various tumors

After 48 hours of treatment with four concentrations of experimental and control groups, the apoptosis rates of Hep-2 cells were (3.95 ± 0.68)%, (8.54 ± 1.35)%, (21.28 ± 2.32)%, (38.65 ± 4.85)%, and (4.26 ± 0.58)%, respectively. Indicating that indole-3-methanol inhibits Hep-2 proliferation in a concentration dependent manner, induces cell apoptosis and Livin protein expression. Indole-3-methanol can inhibit Hep-2 cell proliferation, and its induction of apoptosis may be related to the inhibition of Livin protein expression. As the concentration of indole-3-methanol increased, the expression of Livin gradually decreased, indicating a negative correlation between the expression of Livin protein and the apoptosis rate of human laryngeal cancer cell line Hep-2 after indole-3-methanol treatment. This suggests that Livin protein may play a certain role in the process of indole-3-methanol induced apoptosis of human laryngeal cancer cells. Indole-3-methanol can only induce apoptosis in cancer cells and is safe for non tumor cells without cytotoxicity [8]. Due to its efficient, non-toxic, and natural anti-tumor properties, indole-3-methanol can be one of the candidates for tumor prevention and treatment drugs. The molecular mechanism of indole-3-methanol inhibiting laryngeal cancer cells still needs further research to provide a theoretical basis for future clinical drug research.