CasNo.118-48-9,High quality of Isatoic Anhydride,(118-48-9) Suppliers

1 Kilogram	FOB Price: USD 25.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T,MoneyGram

Keywords

1,2-Dihydro-3,1-benzoxazine-2,4-dione 2-(carboxyamino)-benzoicacicyclicanhydride 2,4-Dioxo-1,2-dihydro-4H-3,1-benzoxazine

Quick Details

Appearance:Beige to brown powder
Application: Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.
PackAge:carton boc
ProductionCapacity:1000000|Kilogram|Month
Storage:cool and dry
Transportation:by air or by sea or by express

Superiority:

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in lead acetate, diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.

1. Rich experience.Having been specialized in this field for years, we have rich experience and widespread sales network around the word. Our hormones have been exported to overseas, like Europe, Africa, Asia, America and other countries. We are not got good feedback from our guest, but also established long business relationship with them.

2. Great quality and high purity.Good quality is one secret for our success. All of our products enjoys high purity. Thus, it can make sure our client's need. Welcome order the samples, MOQ just 10 grams.

3. Safest and fastest delivery.We have mass stock, so that we can arrange the delivery within 24hours once receiving the payment. Tracking number would be informed quickly after shipment. We have our own way of packing which could ship 0.01 kilo to 50 kilo products a time.

4. Good after-sales service.24/7 is available. We will tell you the package updated info ASAP. And try our best to solve various problems customers encountered!

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Our Advantages
1.Own chemical factory

2.Abundant professional production experience

3.Sample is free of charge and in stock with fast delivery

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6.Easily customs clearance, we're very good to all these controls

7.Dedicated researchers to make your customization.

Details:

Product details

CAS:	118-48-9
MF:	C8H5NO3
MW:	163.13
EINECS:	204-255-0
Product Categories:	Pharmaceutical Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;pharmacetical;118-48-9
Mol File:	118-48-9.mol

Isatoic Anhydride Chemical Properties

Melting point	233 °C (dec.) (lit.)
Boiling point	290.19°C (rough estimate)
density	1,52 g/cm³
vapor density	5.6 (vs air)
refractive index	1.5510 (estimate)
Fp	308 °C
storage temp.	Store below +30°C.
solubility	0.3g/l
pka	11.06±0.20(Predicted)
form	Powder
color	Beige to brown
Water Solubility	decomposes
Sensitive	Moisture Sensitive
BRN	136786
LogP	0.978 (est)
CAS DataBase Reference	118-48-9(CAS DataBase Reference)
NIST Chemistry Reference	Isatoic anhydride(118-48-9)
EPA Substance Registry System	2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9)

Isatoic Anhydride Usage And Synthesis

Synthesis	Isatoic Anhydride is synthesized from indole (9a) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature. ¹ H NMR (DMSO-d6): δ11.73 (s, br., 1H), 7.92 (d, J = 7.8 Hz, 1H), 7.74 (t, J = 7.8 Hz, 1H), 7.26 (t, J = 7.8 Hz, 1H), 7.16 (d, J = 7.8 Hz, 1H).
Chemical Properties	BEIGE TO BROWN POWDER
Uses	Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.
Definition	A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthranilic acid derivatives by reaction with hydrogen.
Preparation	Phosphorus tribromide (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic acid (0.1 mol;prepared by coupling anthranilic acid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl ether (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl ether, and recrystallized from ethanol. Yield ca. 90%.
Flammability and Explosibility	Non flammable
Purification Methods	Recrystallise it from EtOH or 95% EtOH (30mL/g) or dioxane (10mL/g) and dry it in a vacuum. [Wagner & Fegley Org Synth Coll Vol III 488 1955, Ben-Ishai & Katchalski J Am Chem Soc 74 3688 1952, UV: Zentmyer & Wagner J Org Chem 14 967 1949, Beilstein 27 II 299, 27III/IV 3330.]

Product usage

Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.

Company profile

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in lead acetate, diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production enterprises.Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.