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factory supply GMP,DMF Sofosbuvir 1190307-88-0
factory supply GMP,DMF Sofosbuvir 1190307-88-0
factory supply GMP,DMF Sofosbuvir 1190307-88-0
factory supply GMP,DMF Sofosbuvir 1190307-88-0

factory supply GMP,DMF Sofosbuvir 1190307-88-0

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: USP/EP/BP
  • Payment Terms : L/C,T/T,Other

Keywords

Sofosbuvir HCV 1190307-88-0

Quick Details

  • Appearance:White crystallization
  • Application:anti-HCV drugs
  • PackAge:1kg/tin
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:
  • Transportation:AIR SEA TRAIN

Superiority:

We are very compeitive on Sofosbuvir.Our mfr is GMP certified for this item with DMF document. 

Product Name: Sofosbuvir
CAS: 1190307-88-0
MF: C22H29FN3O9P
MW: 529.45
EINECS: 695-717-4
Product Categories: Pharmaceutical intermediate;Liver Disease Series;PSI7977;API;Inhibitors;1190307-88-0
Mol File: 1190307-88-0.mol
Sofosbuvir Structure
 
Sofosbuvir Chemical Properties
Melting point  122-124°C
density  1.41
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 9.39±0.10(Predicted)
color  White
InChIKey TTZHDVOVKQGIBA-YBSJRAAASA-N
SMILES C(OC(C)C)(=O)[C@@H](N[P@@](OC[C@@H]1[C@@H](O)[C@](F)(C)[C@H](N2C(=O)NC(=O)C=C2)O1)(OC1=CC=CC=C1)=O)C
CAS DataBase Reference 1190307-88-0

Details:

Abacavir sulfate Chemical Properties
Melting point  222-225°C
storage temp.  2-8°C
solubility  H2O: ≥17mg/mL
form  powder
color  white to tan
optical activity [α]/D -30 to -40°, c = 0.5 in methanol
Water Solubility  1.68ug/L(32 ºC)
CAS DataBase Reference 188062-50-2(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xn
Risk Statements  63-40
Safety Statements  36/37
WGK Germany  3
HS Code  2933595960
Hazardous Substances Data 188062-50-2(Hazardous Substances Data)
 
Abacavir sulfate Usage And Synthesis
Description Abacavir sulfate was first launched as Ziagen in the US for the treatment of human immunodeficiency virus (HIV) infection, in combination with other antiretroviral drugs. Abacavir is a carbocyclic nucleoside reverse transcriptase inhibitor (nRTI); it is one of the most potent anti-HIV agents to date. The compound can be prepared by an enantioselective synthesis involving palladium-catalyzed coupling of a chloropurine with a carbocyclic allylic diacetate. In vitro, Abacavir is a potent and selective inhibitor of HIV-1 and HIV-2 replication. Resistance to Abacavir develops more slowly than for other anti-HIV agents. Abacavir is highly synergistic with protease inhibitors such as Amprenavir. In clinical trials for HIV infections in adults, it produced durable suppression in viral load. Combinations with different protease inhibitors such as Nelfinavir, Saquinavir or Indinavir markedly reduced plasma viral load to undetectable levels for at least 48 weeks, and significantly raised CD4+ cell counts in adults with HIV infection, especially nRTI-naive patients. Abacavir has a good oral availability and its penetration into CSF is much more significant than for other anti-HIV drugs. The two major metabolites identified in humans were the 5'-carboxylate and the 5'-glucuronide, mainly excreted via the renal route.
Chemical Properties White Solid

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