CasNo.881674-56-2,High quality of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde,(881674-56-2) Suppliers

1 Kilogram	FOB Price: USD 25.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T,

Keywords

TAK438 Impurity 54 CAS 881674-56-2 TAK-438( Vonoprazan fumarate) intermediate 3

Quick Details

Appearance:Light Brown to Brown solid
Application:5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
PackAge:carton boc
ProductionCapacity:1000000|Kilogram|Month
Storage:cool and dry
Transportation:by air or by sea or by express

Superiority:

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in lead acetate, diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.

Details:

Product details

CAS:	881674-56-2
MF:	C11H8FNO
MW:	189.19
EINECS:	809-913-6
Product Categories:	Vonoprazan;Pharmaceutical Intermediates;881674-56-2
Mol File:	881674-56-2.mol

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties

Melting point	133 °C
Boiling point	370.6±32.0 °C(Predicted)
density	1.270±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	14.77±0.50(Predicted)
color	Light Brown to Brown
Stability:	Hygroscopic
InChI	InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H
InChIKey	MQULPEUCGKEHEG-UHFFFAOYSA-N
SMILES	N1C(C2=CC=CC=C2F)=CC(C=O)=C1

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Usage And Synthesis

Description	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases.
Chemical Properties	Light orange to Yellow to Green powder to crystal.
Uses	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
Preparation	Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
Definition	The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material.

Company profile

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in lead acetate, diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production enterprises.Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.