Caffeic acid

Details:

[Plant sources] Compositae Solidago Solidago virga-urea L.var.leiocarpa (Benth.) A. Gray Herba [Chemical Name] 2-Propenoic acid, 3 - (3,4-dihydroxy-phenyl) -- [Molecular formula] C9H8O4; [Molecular Weight] 180.15 [Physical Properties] from the thick yellow aqueous solution was the crystallization of a dilute aqueous solution from one hydrate. Decomposition point 223 ~ 225 ° (softening at 194 °). Slightly soluble in cold water, soluble in hot water and cold ethanol. [Pharmacological actions] 1. Antimicrobial anti-virus: with a wider range of antibacterial effect, but the protein can be inactivated in the body. In vitro tests showed that there is anti-viral activity of the cowpox virus and adenovirus strong inhibitory effect, followed by poliovirus type Ⅰ and type Ⅲ parainfluenza virus. 2. Anti-venom: caffeic acid 3 mg dose completely inhibited when the ring for the end of 20 micrograms of snake venom phosphodiesterase for the anti-venom agents. 3. Other effects: oral or intraperitoneal injection, the caffeic acid can enhance the central excitability rats; oral, people can increase the secretion of stomach hydrochloric acid, and can slow the pulse; uterus to enhance the tension, the effect of the antagonist was papaverine, and atropine can not be affected; to promote bile secretion in rats. Have elevated white blood cell, bleeding and the role of inactivation, such as vitamin B1. Can inhibit the rat brain tissue lipid peroxide formation. Have to shorten the coagulation and bleeding time. 4. Toxicity: LD50 for mice by intraperitoneal injection of 1583mg/kg; rabbits intravenously 14mg/kg / day, for ten days, the heart, liver, kidney function and anatomical examination were no pathological changes].