- Min.Order :10 Gram
- Purity: 99%
- Payment Terms : L/C,T/T
Keywords
1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]- Alk 5 Inhibitor II SJN 2511
Quick Details
- Appearance:light yellow powder
- Application:RepSox have been used to transform inhibitors of growth factor beta kinase type 1 receptor (ALK5)
- PackAge:fiber can
- ProductionCapacity:10|Kilogram|Year
- Storage:Store at +4°C
- Transportation: air transport
Superiority:
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Details:
The common name :2-(3-(6-methylpyridine-2-yl) -1h-pyrazole-4-yl)-1, 5-naphthidine
The English name : RepSox
CAS number: 446859-33-2
Molecular weight: 287.319
Density: 1.3± 0.1g /cm3
Boiling point: 501.9±50.0 °C at 760 mmHg
Molecular formula: C17H13N5
Melting point: 195 °C
RepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). RepSox is selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.
RepSox synthesized to Ancillary Material Grade also available.
For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors.
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