Erlotinib hydrochloride

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1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T

Keywords

4-Quinazolinamine,N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, monohydrochloride (9CI) 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride CP358774

Quick Details

Appearance:white powder
Application:Second - or third-line treatment of locally advanced or metastatic non-small cell lung cancer and treatment of pancreatic cancer
PackAge:fiber can
ProductionCapacity:200|Kilogram|Year
Storage:store at 2-8℃
Transportation:air transport

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Details:

CAS number :183319-69-9
English name :Erlotinibhydrochloride English alias :ERLOTINIBHCL; Tarceva; ErL; Erlotinib,HydrochlorideSalt; CS-491; OSI774; RG-1415; CP358774; NSC718781; ChemicalbookRO-0508231API
Molecular formula :C22H24ClN3O4
Molecular weight :429.9

Chemical properties Melting point :223-225°C
Storage conditions: Inertatmosphere Storeinfreezer, under - 20 ° C
Solubility SolubleinDMSO(upto18mg/mlwithwarming)
Acidity factor (pKa):pKa(25°):5.Chemicalbook42 Form :Yellowpowder.
Color :Whiteoroff-white

Stability Stablefor1yearfromdateofpurchaseassupplied. SolutionsinDMSOmaybestoredat - 20 ° forupto3months.

Erlotinib hydrochloride is a small molecule epidermal growth factor receptor tyrosine kinase reversible inhibitor, mainly used in the treatment of locally advanced or metastatic non-small cell lung cancer second or third line treatment and pancreatic cancer.

Erlotinib targets the epidermal growth factor receptor subtype (EGFR-TK) that reversibly and selectively acts on tyrosine kinase receptors. Its mechanism of action is to compete with substrates in the cell, inhibit EGFR-TK phosphorylation, block tumor cell signaling, inhibit tumor cell growth, and induce apoptosis. Clinical studies have shown that the drug has an inhibitory effect on a variety of tumors. Compared with traditional chemotherapy drugs, it has the advantages of less adverse reactions, better safety and tolerance.

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