- Min.Order :100 Gram
- Purity: 99%
- Payment Terms : L/C,T/T
Keywords
2-((S)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile 2-Piperazineacetonitrile, 4-(7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-(((2S)-1-methyl-2-pyrrolidinyl)methoxy)pyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)- adagrasib
Quick Details
- Appearance:white powder
- Application:Covalent inhibition of KRAS 12C with potential antitumor activity
- PackAge:fiber can
- ProductionCapacity:100|Kilogram|Year
- Storage:store at 2-8℃
- Transportation:air transport
Superiority:
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Details:
CAS number :2326521-71-3
English name :MRTX-849 English alias :Adagrasib; 2 - (4 - ((S) - 7 - (8 - chloronaphthalen - 1 - yl) - 2 - (((S) - 1 - methylpyrrolidin - 2 - yl) methoxy) - 5,6,7,8 - tetrahydropyrido pyrimidin - [3, 4 - d] 4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile; MRTX-849; Adagrasib/MRTX-849; MRTX849(Adagrasib); AzvudineImpurity23; MRTX849; MRTX-Chemicalbook849; MRTX849; 4 - [7-8 - CHLORO - 1 - (NAPHTHALENYL) - 5,6,7,8 - TETRAHYDRO - 2 - [[(2 s) - 1 - METHYL - 2 - PYRR; 4 - [2 - PIPERAZINEACETONITRILE, 7-8 - CHLORO - 1 - (NAPHTHALENYL) - 5,6,7,8 - TETRAHYDRO - 2 - [[(2 s) - 1 - METHYL - 2 - PYRR; 4 - [2 - PIPERAZINEACETONITRILE, 7-8 - CHLORO - 1 - (NAPHTHALENYL) - 5, Chemicalbook6, 7, 8 - TETRAHYDRO - 2 - [[(2 s) - 1 - METHYL - 2 - PYRR
Molecular formula:
C32H35ClFN7O2
Molecular weight:
604.12
Boiling point 860.2±75.0 °C(Predicted)
Density 1.295± 0.06g /cm3(Predicted)
Storage conditions -20°C
Soluble in DMSO:1.0(Max Conc.mg /mL); 1.7(Max Conc.mM)
Acidity coefficient (pKa)9.31±0.40(Predicted)
Morphological crystalline solid
MRTX-849 is indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with KRASG12C mutation who have previously received at least one systemic therapy.
Biological activity
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