Nicotinamide

Details:

 Nicotinamide (Niacinamide) Product Details

**1. Basic Information:**

- Chemical Name: Nicotinamide
- Alternative Name: Niacinamide, Vitamin B3 (when referring to its broader category)
- Chemical Formula: C?H?N?O
- Molecular Weight: 122.12 g/mol
- CAS Number: 98-92-0

2. Physical Properties:

- **Appearance:** White, crystalline powder or solid
- Odor: Odorless
- Solubility: Soluble in water, ethanol, and glycerin
- Melting Point: Approximately 130-140 °C (266-284 °F)

3. Chemical Properties:

- pH: Nicotinamide is mildly acidic or neutral in aqueous solutions.
- Stability:** Generally stable under normal storage conditions. Sensitive to strong acids and bases.

4. Common Forms and Packaging:

- Powder Form: Available as a white crystalline powder, often packaged in airtight containers to protect from moisture.
- Solutions and Creams: Incorporated into various skincare formulations such as serums, creams, and lotions.
- Capsules/Tablets: Available as dietary supplements in various dosages.

5. Production:

- **Synthetic Production:** Nicotinamide is typically synthesized chemically through the oxidation of nicotine or the reaction of niacin (another form of Vitamin B3) with ammonia.

6. Applications:

- Skincare:
  - Anti-Aging: Reduces fine lines and wrinkles, improves skin elasticity.
  - Brightening: Evens out skin tone and reduces hyperpigmentation.
  - Anti-Inflammatory: Soothes irritated skin and reduces redness.
  - Moisturizing: Strengthens skin barrier function and retains moisture.
  - Sun Protection: Enhances skin’s resistance to UV damage.

- Health Supplements:
  - Vitamin B3 Source: Supports metabolism, energy production, and DNA repair.
  - Skin Health: May aid in managing skin conditions from within.

- Pharmaceuticals:
  - Treatment of Skin Disorders: Used in topical treatments for acne, dermatitis, and other skin conditions.
  - Potential Neuroprotective Benefits: Research suggests possible benefits in neurodegenerative disease management.

- Cosmetics:
  - Stable Ingredient: Maintains efficacy in various formulations.
  - Compatible: Works well with other active skincare ingredients like retinoids and hyaluronic acid.

7. Safety and Handling:

- Toxicity: Nicotinamide is generally considered safe for topical and oral use. Excessive oral intake may cause nausea or liver issues, but such cases are rare with typical dosages.
- Irritation: Topical use is usually well-tolerated, but sensitivity can occur in some individuals. It is advised to perform a patch test before extensive use.
- Storage: Store in a cool, dry place, away from moisture and strong light. For formulations, follow specific product storage instructions.

8. Environmental and Regulatory Information:

- Disposal: Nicotinamide should be disposed of according to local regulations. It is not classified as hazardous waste.
- Labels: Products containing nicotinamide should include clear labeling and safety data sheets (SDS) with handling instructions.

9. Economic and Practical Considerations:

- Cost-Effectiveness: Nicotinamide is relatively affordable, making it a cost-effective choice for both manufacturers and consumers.
- Versatility: Its benefits extend across skincare, health supplements, and pharmaceuticals, allowing it to be used in a wide range of products.

### Summary

Nicotinamide (niacinamide) is a valuable compound in skincare and health, known for its stability, versatility, and multiple benefits. Its uses range from improving skin appearance and treating various skin conditions to supporting overall health as a dietary supplement. Its safe profile, coupled with its cost-effectiveness, makes it a popular ingredient in many formulations.